The biology of prostaglandins and their role as a target for allergic airway disease therapy

Kijeong Lee, Sang Hag Lee, Tae Hoon Kim

Research output: Contribution to journalReview articlepeer-review

30 Citations (Scopus)

Abstract

Prostaglandins (PGs) are a family of lipid compounds that are derived from arachidonic acid via the cyclooxygenase pathway, and consist of PGD2, PGI2, PGE2, PGF2, and thromboxane B2. PGs signal through G-protein coupled receptors, and individual PGs affect allergic inflammation through different mechanisms according to the receptors with which they are associated. In this review article, we have focused on the metabolism of the cyclooxygenase pathway, and the distinct biological effect of each PG type on various cell types involved in allergic airway diseases, including asthma, allergic rhinitis, nasal polyposis, and aspirin-exacerbated respiratory disease.

Original languageEnglish
Article number1851
JournalInternational journal of molecular sciences
Volume21
Issue number5
DOIs
Publication statusPublished - 2020 Mar 1

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program, National Research Foundation of Korea, funded by the Ministry of Science and Technology and the Ministry of Science, ICT & Future Planning (2017R1A2B2003575), and the Korea Health Technology R&D Project (HI17C0387), Korea Health Industry Development Institute (KHIDI), and the Ministry of Health & Welfare. This research was also supported by a Korea University grant, and a grant from Korea University Medical Center as well as by Anam Hospital, Seoul, Republic of Korea (O1905011).

Funding Information:
Funding: This research was supported by the Basic Science Research Program, National Research Foundation of Korea, funded by the Ministry of Science and Technology and the Ministry of Science, ICT & Future Planning (2017R1A2B2003575), and the Korea Health Technology R&D Project (HI17C0387), Korea Health Industry Development Institute (KHIDI), and the Ministry of Health & Welfare. This research was also supported by a Korea University grant, and a grant from Korea University Medical Center as well as by Anam Hospital, Seoul, Republic of Korea (O1905011).

Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • AERD
  • Allergic rhinitis
  • Allergy
  • Asthma
  • PGD
  • PGE
  • Prostaglandins

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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