The bond survival time variation of polymorphic amyloid fibrils in the mechanical insight

Myeongsang Lee; Inchul Baek; Hyun Joon Chang; Gwonchan Yoon; Sungsoo Na

doi:10.1016/j.cplett.2014.03.043

The bond survival time variation of polymorphic amyloid fibrils in the mechanical insight

Myeongsang Lee, Inchul Baek, Hyun Joon Chang, Gwonchan Yoon, Sungsoo Na

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

The structure-property relationships of biological materials such as amyloid fibrils are important to developing therapeutic strategies for amyloid-related diseases. The mechanical characterization of biological materials can provide insight into such relationships. In this study, polymorphic human islet polypeptide (hIAPP) fibrils were constructed with molecular modeling, and a constant-force bending simulation was performed to characterize the different mechanical behaviors of polymorphic hIAPP protofibrils. Our simulation results showed that, owing to their different intramolecular interactions, the fracture times of polymorphic hIAPP protofibrils depend on polymorphic structures.

Original language	English
Pages (from-to)	68-72
Number of pages	5
Journal	Chemical Physics Letters
Volume	600
DOIs	https://doi.org/10.1016/j.cplett.2014.03.043
Publication status	Published - 2014 Apr 29

Bibliographical note

Funding Information:
S.N. gratefully acknowledges the financial support from NRF under Grant Nos. 2011-0007272 , 2011-0029477 , and 2012-0000785 . G.Y. is grateful to the financial support from NRF under Grant No. 2012R1A1A2038373 and Korea University Grant.

ASJC Scopus subject areas

General Physics and Astronomy
Physical and Theoretical Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.cplett.2014.03.043

Cite this

@article{52bf34f342c744109d31bf3f5b4e2112,

title = "The bond survival time variation of polymorphic amyloid fibrils in the mechanical insight",

abstract = "The structure-property relationships of biological materials such as amyloid fibrils are important to developing therapeutic strategies for amyloid-related diseases. The mechanical characterization of biological materials can provide insight into such relationships. In this study, polymorphic human islet polypeptide (hIAPP) fibrils were constructed with molecular modeling, and a constant-force bending simulation was performed to characterize the different mechanical behaviors of polymorphic hIAPP protofibrils. Our simulation results showed that, owing to their different intramolecular interactions, the fracture times of polymorphic hIAPP protofibrils depend on polymorphic structures.",

author = "Myeongsang Lee and Inchul Baek and Chang, {Hyun Joon} and Gwonchan Yoon and Sungsoo Na",

note = "Funding Information: S.N. gratefully acknowledges the financial support from NRF under Grant Nos. 2011-0007272 , 2011-0029477 , and 2012-0000785 . G.Y. is grateful to the financial support from NRF under Grant No. 2012R1A1A2038373 and Korea University Grant. ",

year = "2014",

month = apr,

day = "29",

doi = "10.1016/j.cplett.2014.03.043",

language = "English",

volume = "600",

pages = "68--72",

journal = "Chemical Physics Letters",

issn = "0009-2614",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - The bond survival time variation of polymorphic amyloid fibrils in the mechanical insight

AU - Lee, Myeongsang

AU - Baek, Inchul

AU - Chang, Hyun Joon

AU - Yoon, Gwonchan

AU - Na, Sungsoo

N1 - Funding Information: S.N. gratefully acknowledges the financial support from NRF under Grant Nos. 2011-0007272 , 2011-0029477 , and 2012-0000785 . G.Y. is grateful to the financial support from NRF under Grant No. 2012R1A1A2038373 and Korea University Grant.

PY - 2014/4/29

Y1 - 2014/4/29

N2 - The structure-property relationships of biological materials such as amyloid fibrils are important to developing therapeutic strategies for amyloid-related diseases. The mechanical characterization of biological materials can provide insight into such relationships. In this study, polymorphic human islet polypeptide (hIAPP) fibrils were constructed with molecular modeling, and a constant-force bending simulation was performed to characterize the different mechanical behaviors of polymorphic hIAPP protofibrils. Our simulation results showed that, owing to their different intramolecular interactions, the fracture times of polymorphic hIAPP protofibrils depend on polymorphic structures.

AB - The structure-property relationships of biological materials such as amyloid fibrils are important to developing therapeutic strategies for amyloid-related diseases. The mechanical characterization of biological materials can provide insight into such relationships. In this study, polymorphic human islet polypeptide (hIAPP) fibrils were constructed with molecular modeling, and a constant-force bending simulation was performed to characterize the different mechanical behaviors of polymorphic hIAPP protofibrils. Our simulation results showed that, owing to their different intramolecular interactions, the fracture times of polymorphic hIAPP protofibrils depend on polymorphic structures.

UR - http://www.scopus.com/inward/record.url?scp=84898603428&partnerID=8YFLogxK

U2 - 10.1016/j.cplett.2014.03.043

DO - 10.1016/j.cplett.2014.03.043

M3 - Article

AN - SCOPUS:84898603428

SN - 0009-2614

VL - 600

SP - 68

EP - 72

JO - Chemical Physics Letters

JF - Chemical Physics Letters

ER -

The bond survival time variation of polymorphic amyloid fibrils in the mechanical insight

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this