The BTBD9 gene may be associated with antipsychotic-induced restless legs syndrome in schizophrenia

Seung Gul Kang, Heon Jeong Lee, Young Min Park, Hee Jung Yang, Hyun Mi Song, Yu Jin Lee, Seong Jin Cho, Sung Nam Cho, Leen Kim

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Objective A genome-wide association study and several replication studies have shown significant association between BTBD9 gene single nucleotide polymorphisms and restless legs syndrome (RLS). The aim of this study is to investigate the association between the BTBD9 gene polymorphisms and antipsychotic-induced RLS in schizophrenic patients. Methods Restless legs syndrome symptoms were evaluated using the diagnostic criteria of the International Restless Legs Syndrome Study Group in 190 Korean schizophrenic patients. We genotyped the rs9357271 and rs3923809 polymorphisms of the BTBD9 gene in schizophrenic patients with (n = 96) and without (n = 94) RLS symptoms. Results There was a significant difference in the allele frequency (χ2 = 8.14, p = 0.004) of the rs9357271 polymorphism between schizophrenic patients with and without RLS symptoms. Significant genotypic association of this single nucleotide polymorphisms with RLS symptoms was also observed for the dominant model (χ2 = 10.32, p = 0.001) and heterozygous model (χ2 = 10.9, p = 0.001). When we compared the frequencies of the rs3923809-rs9357271 haplotypes between the two groups, the overall haplotype frequencies were significantly different (permuted p = 0.037), and the A-T haplotype was significantly more frequent in the RLS symptom group than in the no RLS symptom group (0.112 vs. 0.041, permuted p = 0.007). Conclusions These data suggest that the BTBD9 gene is associated with antipsychotic-induced RLS symptoms in schizophrenic patients.

Original languageEnglish
Pages (from-to)117-123
Number of pages7
JournalHuman Psychopharmacology
Issue number2
Publication statusPublished - 2013 Mar


  • BTBD9 gene
  • antipsychotics
  • polymorphism
  • restless legs syndrome
  • schizophrenia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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