The crystal structure of an HSL-homolog EstE5 complex with PMSF reveals a unique configuration that inhibits the nucleophile Ser144 in catalytic triads

Keyphrases

• Hormone-sensitive Lipase 100%
• Esterase 100%
• Catalytic Triad 100%
• Nucleophile 100%
• HSL Family 100%
• Lipase 50%
• Microorganisms 50%
• Functional Analysis 50%
• Fat Cells 50%
• Lipolysis 50%
• Specific Enzymes 50%
• Adipose Tissue 50%
• Metagenomic Library 50%
• Rodents 50%
• Structural Characterization 50%
• Diverse Groups 50%
• Hydrolases 50%
• Serine Protease 50%
• Ester Bond 50%
• Lipase Inhibitor 50%
• Structural Configuration 50%
• EC 3.1.1.3 50%
• Biological Characterization 50%

Biochemistry, Genetics and Molecular Biology

• Crystal Structure 100%
• Catalytic Triad 100%
• PMSF 100%
• Enzyme 50%
• Triacylglycerol Lipase 50%
• Pancreatic Lipase 50%
• Hormone-Sensitive Lipase 50%
• Esterase 50%
• Adipocyte 25%
• Lipolysis 25%
• Metagenome 25%
• Microorganism 25%
• Hydrolase 25%
• Serine Protease 25%