The Detection of Urinary Exosomal miRNAs for Cancer Diagnostics and Prognostics

Junbeom Kim; Mina Kim; Ji Yoon Kang; Ki Wan Bong; Nakwon Choi

doi:10.1007/s13206-023-00108-0

The Detection of Urinary Exosomal miRNAs for Cancer Diagnostics and Prognostics

Junbeom Kim, Mina Kim, Ji Yoon Kang, Ki Wan Bong, Nakwon Choi

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

Liquid biopsy is a non-invasive diagnostic method that utilizes the detection and analysis of biomarkers in bodily fluids for the diagnosis and prognosis of various diseases. Exosomal microRNAs (miRNAs), which are remarkably stable because of the protection by extracellular vesicles (EVs), in liquid biopsy have gained considerable attention as they can regulate gene expression and serve as crucial biomarkers for the presence and progression of different types of cancer. Especially, urinary exosomal miRNAs have shown promising results as biomarkers for cancer from the urogenital system, such as bladder, renal tubular, and prostate. However, there are still significant challenges hindering the clinical utilization of urinary exosomal miRNA biomarkers, including improper sample handling, and data bias. Therefore, the detection procedure of urinary exosomal miRNAs needs to be standardized and thoroughly reviewed to ensure accurate and reliable clinical results. In this review, we have explored various detection procedures for urinary exosomal miRNAs, which have great potential as biomarkers for cancer diagnostics and prognostics.

Original language	English
Pages (from-to)	308-317
Number of pages	10
Journal	Biochip Journal
Volume	17
Issue number	3
DOIs	https://doi.org/10.1007/s13206-023-00108-0
Publication status	Published - 2023 Sept

Bibliographical note

Funding Information:
This journal was supported by the Ministry of Science and ICT through the National Research Foundation of Korea (NRF): NRF-2020M3A9D8039920, NRF-2021M3H4A4079294, NRF-2022M3A9B6082678, NRF-2016R1A5A1010148 (the Engineering Research Center of Excellence Program). We also acknowledge support jointly from the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health and Welfare, and the Ministry of Food and Drug Safety: KMDF_PR_20200901_0072 (the Korea Medical Device Development Fund). We acknowledge support from the KIST institutional project (2E31502) and the KU-KIST Graduate School of Converging Science and Technology Program. This research was also supported by the Technology Innovation Program (20018111, Development of super-fast multiplex technology for the examination of diagnosis of infectious disease and in-body response test) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea).

Publisher Copyright:
© 2023, The Korean BioChip Society.

Keywords

Cancer
Exosomal miRNAs
Extracellular vesicle (EVs)
Liquid biopsy
Urinary exosomal miRNAs

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s13206-023-00108-0

Cite this

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title = "The Detection of Urinary Exosomal miRNAs for Cancer Diagnostics and Prognostics",

abstract = "Liquid biopsy is a non-invasive diagnostic method that utilizes the detection and analysis of biomarkers in bodily fluids for the diagnosis and prognosis of various diseases. Exosomal microRNAs (miRNAs), which are remarkably stable because of the protection by extracellular vesicles (EVs), in liquid biopsy have gained considerable attention as they can regulate gene expression and serve as crucial biomarkers for the presence and progression of different types of cancer. Especially, urinary exosomal miRNAs have shown promising results as biomarkers for cancer from the urogenital system, such as bladder, renal tubular, and prostate. However, there are still significant challenges hindering the clinical utilization of urinary exosomal miRNA biomarkers, including improper sample handling, and data bias. Therefore, the detection procedure of urinary exosomal miRNAs needs to be standardized and thoroughly reviewed to ensure accurate and reliable clinical results. In this review, we have explored various detection procedures for urinary exosomal miRNAs, which have great potential as biomarkers for cancer diagnostics and prognostics.",

keywords = "Cancer, Exosomal miRNAs, Extracellular vesicle (EVs), Liquid biopsy, Urinary exosomal miRNAs",

author = "Junbeom Kim and Mina Kim and Kang, {Ji Yoon} and Bong, {Ki Wan} and Nakwon Choi",

note = "Funding Information: This journal was supported by the Ministry of Science and ICT through the National Research Foundation of Korea (NRF): NRF-2020M3A9D8039920, NRF-2021M3H4A4079294, NRF-2022M3A9B6082678, NRF-2016R1A5A1010148 (the Engineering Research Center of Excellence Program). We also acknowledge support jointly from the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health and Welfare, and the Ministry of Food and Drug Safety: KMDF_PR_20200901_0072 (the Korea Medical Device Development Fund). We acknowledge support from the KIST institutional project (2E31502) and the KU-KIST Graduate School of Converging Science and Technology Program. This research was also supported by the Technology Innovation Program (20018111, Development of super-fast multiplex technology for the examination of diagnosis of infectious disease and in-body response test) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea). Publisher Copyright: {\textcopyright} 2023, The Korean BioChip Society.",

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AU - Kim, Junbeom

AU - Kim, Mina

AU - Kang, Ji Yoon

AU - Bong, Ki Wan

AU - Choi, Nakwon

N1 - Funding Information: This journal was supported by the Ministry of Science and ICT through the National Research Foundation of Korea (NRF): NRF-2020M3A9D8039920, NRF-2021M3H4A4079294, NRF-2022M3A9B6082678, NRF-2016R1A5A1010148 (the Engineering Research Center of Excellence Program). We also acknowledge support jointly from the Ministry of Science and ICT, the Ministry of Trade, Industry and Energy, the Ministry of Health and Welfare, and the Ministry of Food and Drug Safety: KMDF_PR_20200901_0072 (the Korea Medical Device Development Fund). We acknowledge support from the KIST institutional project (2E31502) and the KU-KIST Graduate School of Converging Science and Technology Program. This research was also supported by the Technology Innovation Program (20018111, Development of super-fast multiplex technology for the examination of diagnosis of infectious disease and in-body response test) funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea). Publisher Copyright: © 2023, The Korean BioChip Society.

PY - 2023/9

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N2 - Liquid biopsy is a non-invasive diagnostic method that utilizes the detection and analysis of biomarkers in bodily fluids for the diagnosis and prognosis of various diseases. Exosomal microRNAs (miRNAs), which are remarkably stable because of the protection by extracellular vesicles (EVs), in liquid biopsy have gained considerable attention as they can regulate gene expression and serve as crucial biomarkers for the presence and progression of different types of cancer. Especially, urinary exosomal miRNAs have shown promising results as biomarkers for cancer from the urogenital system, such as bladder, renal tubular, and prostate. However, there are still significant challenges hindering the clinical utilization of urinary exosomal miRNA biomarkers, including improper sample handling, and data bias. Therefore, the detection procedure of urinary exosomal miRNAs needs to be standardized and thoroughly reviewed to ensure accurate and reliable clinical results. In this review, we have explored various detection procedures for urinary exosomal miRNAs, which have great potential as biomarkers for cancer diagnostics and prognostics.

AB - Liquid biopsy is a non-invasive diagnostic method that utilizes the detection and analysis of biomarkers in bodily fluids for the diagnosis and prognosis of various diseases. Exosomal microRNAs (miRNAs), which are remarkably stable because of the protection by extracellular vesicles (EVs), in liquid biopsy have gained considerable attention as they can regulate gene expression and serve as crucial biomarkers for the presence and progression of different types of cancer. Especially, urinary exosomal miRNAs have shown promising results as biomarkers for cancer from the urogenital system, such as bladder, renal tubular, and prostate. However, there are still significant challenges hindering the clinical utilization of urinary exosomal miRNA biomarkers, including improper sample handling, and data bias. Therefore, the detection procedure of urinary exosomal miRNAs needs to be standardized and thoroughly reviewed to ensure accurate and reliable clinical results. In this review, we have explored various detection procedures for urinary exosomal miRNAs, which have great potential as biomarkers for cancer diagnostics and prognostics.

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The Detection of Urinary Exosomal miRNAs for Cancer Diagnostics and Prognostics

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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