The development of evidence-based guideline for diagnosis and management of headache in Korea

Sun Mi Kim, Young Hoon Ko, Seoyoung Yoon, Won Sub Kang, Hye Geum Kim, Hye Youn Park, Cheolmin Shin, Yoo Hyun Um, Soyoung Youn, Jae Hon Lee, Seung Ho Jang, Sang Won Jeon, Hong Jun Jeon, Seockhoon Chung, Jae Won Choi, Kyu Man Han, Sang Yeol Lee

    Research output: Contribution to journalArticlepeer-review

    2 Citations (Scopus)


    Objective We aimed to develop the clinical guideline for headache by the systematic review and synthesis of existing evidence-based guidelines. The purpose of developing the guideline was to improve the appropriateness of diagnosis and treatment of headache disorder, and consequently, to improve patients’ pain control and quality of life. The guideline broadly covers the differential diagnosis and treatment of tension-type headache, migraine, cluster headache, and medication-overuse headache. Methods This is a methodological study based on the ADAPTE methodology, including a systematic review of the literature, quality assessment of the guidelines using the Appraisal of Clinical Guidelines for REsearch & Evaluation II (AGREE II) Instrument, as well as an external review using a Delphi technique. The inclusion criteria for systematic search were as follows: topic-relevant, up-to-date guidelines including evidence from within 5 years, evidence-based guidelines, guidelines written in English or Korean, and guidelines issued by academic institutions or government agencies. Results We selected five guidelines and conducted their quality assessment using the AGREE II Instrument. As a result, one guideline was found to be eligible for adaptation. For 13 key questions, a total of 39 recommendations were proposed with the grading system and revised using the nominal group technique. Conclusion Recommendations should be applied to actual clinical sites to achieve the ultimate goal of this guideline; therefore, followup activities, such as monitoring of guideline usage and assessment of applicability of the recommendations, should be performed in the future. Further assessment of the effectiveness of the guideline in Korea is needed.

    Original languageEnglish
    Pages (from-to)199-205
    Number of pages7
    JournalPsychiatry Investigation
    Issue number3
    Publication statusPublished - 2019 Mar

    Bibliographical note

    Funding Information:
    This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HC17C0117).

    Publisher Copyright:
    © 2019 Korean Neuropsychiatric Association.


    • Cluster headache
    • Guideline
    • Headache
    • Medication-overuse headache
    • Migraine
    • Tension-type headache

    ASJC Scopus subject areas

    • Psychiatry and Mental health
    • Biological Psychiatry


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