The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease

Hyun Kuk Kim; Udaya S. Tantry; Sidney C. Smith; Myung Ho Jeong; Seung Jung Park; Moo Hyun Kim; Do Sun Lim; Eun Seok Shin; Duk Woo Park; Yong Huo; Shao Liang Chen; Zheng Bo; Shinya Goto; Takeshi Kimura; Satoshi Yasuda; Wen Jone Chen; Mark Chan; Daniel Aradi; Tobias Geisler; Diana A. Gorog; Dirk Sibbing; Gregory Y.H. Lip; Dominick J. Angiolillo; Paul A. Gurbel; Young Hoon Jeong

doi:10.1055/s-0040-1718729

The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease

Hyun Kuk Kim, Udaya S. Tantry, Sidney C. Smith, Myung Ho Jeong, Seung Jung Park, Moo Hyun Kim, Do Sun Lim, Eun Seok Shin, Duk Woo Park, Yong Huo, Shao Liang Chen, Zheng Bo, Shinya Goto, Takeshi Kimura, Satoshi Yasuda, Wen Jone Chen, Mark Chan, Daniel Aradi, Tobias Geisler, Diana A. GorogDirk Sibbing, Gregory Y.H. Lip, Dominick J. Angiolillo, Paul A. Gurbel, Young Hoon Jeong

Research output: Contribution to journal › Review article › peer-review

196 Citations (Scopus)

Abstract

East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y 12 receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit trade-off in East Asians has been a topic of emerging interest. In this article, we propose updated evidence and future directions of antithrombotic treatment in East Asian patients.

Original language	English
Pages (from-to)	422-432
Number of pages	11
Journal	Thrombosis and Haemostasis
Volume	121
Issue number	4
DOIs	https://doi.org/10.1055/s-0040-1718729
Publication status	Published - 2021 Apr 1
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020. Thieme. All rights reserved.

Keywords

antiplatelet therapy
bleeding risk
direct oral anticoagulants
ischemic risk
race

ASJC Scopus subject areas

Hematology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1055/s-0040-1718729

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Kim, H. K., Tantry, U. S., Smith, S. C., Jeong, M. H., Park, S. J., Kim, M. H., Lim, D. S., Shin, E. S., Park, D. W., Huo, Y., Chen, S. L., Bo, Z., Goto, S., Kimura, T., Yasuda, S., Chen, W. J., Chan, M., Aradi, D., Geisler, T., ... Jeong, Y. H. (2021). The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease. Thrombosis and Haemostasis, 121(4), 422-432. https://doi.org/10.1055/s-0040-1718729

Kim, HK, Tantry, US, Smith, SC, Jeong, MH, Park, SJ, Kim, MH, Lim, DS, Shin, ES, Park, DW, Huo, Y, Chen, SL, Bo, Z, Goto, S, Kimura, T, Yasuda, S, Chen, WJ, Chan, M, Aradi, D, Geisler, T, Gorog, DA, Sibbing, D, Lip, GYH, Angiolillo, DJ, Gurbel, PA & Jeong, YH 2021, 'The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease', Thrombosis and Haemostasis, vol. 121, no. 4, pp. 422-432. https://doi.org/10.1055/s-0040-1718729

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abstract = "East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y 12 receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit trade-off in East Asians has been a topic of emerging interest. In this article, we propose updated evidence and future directions of antithrombotic treatment in East Asian patients.",

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AU - Bo, Zheng

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AU - Chan, Mark

AU - Aradi, Daniel

AU - Geisler, Tobias

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AU - Sibbing, Dirk

AU - Lip, Gregory Y.H.

AU - Angiolillo, Dominick J.

AU - Gurbel, Paul A.

AU - Jeong, Young Hoon

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AB - East Asian patients have reduced anti-ischemic benefits and increased bleeding risk during antithrombotic therapies compared with Caucasian patients. As potent P2Y 12 receptor inhibitors (e.g., ticagrelor and prasugrel) and direct oral anticoagulants are commonly used in current daily practice, the unique risk-benefit trade-off in East Asians has been a topic of emerging interest. In this article, we propose updated evidence and future directions of antithrombotic treatment in East Asian patients.

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The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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