The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant

Jong Eun Kim; Seong Su Kang; Kyung Hee Choi; June Sung Shim; Chang Mo Jeong; Sang Wan Shin; Jung Bo Huh

doi:10.1016/j.oooo.2011.10.040

The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant

Jong Eun Kim, Seong Su Kang, Kyung Hee Choi, June Sung Shim, Chang Mo Jeong, Sang Wan Shin, Jung Bo Huh

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

Objectives: The aim of this study was to evaluate the effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors (rhVEGFs) on vertical bone regeneration in the marginal portion of the peri-implant. Study Design: Supra-alveolar defects were created in 3 male beagle dogs. Each animal received 8 implants that were either coated with a single growth factor (rhBMP-2) or combined growth factors (rhBMP-2 + rhVEGF), or an anodized implant (the control group). The amount of the vertical bone regeneration, the bone-implant contact, and the intrathread bone density were investigated using histomorphometric analysis at 8 weeks. Results: The bone morphogenetic protein (BMP) group and the BMP-VEGF group showed vertical alveolar bone regeneration and enhanced bone-implant contact in the microthread compared with the control group (P <.05). Conclusions: Anodized implants coated with rhBMP-2 and rhBMP - 2 + rhVEGF can induce vertical alveolar bone regeneration, but the combined effect of rhBMP-2 and rhVEGF was not verified.

Original language	English
Pages (from-to)	e24-e31
Journal	Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume	115
Issue number	6
DOIs	https://doi.org/10.1016/j.oooo.2011.10.040
Publication status	Published - 2013 Jun

ASJC Scopus subject areas

Surgery
Oral Surgery
Pathology and Forensic Medicine
Dentistry (miscellaneous)
Radiology Nuclear Medicine and imaging

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10.1016/j.oooo.2011.10.040

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Kim, J. E., Kang, S. S., Choi, K. H., Shim, J. S., Jeong, C. M., Shin, S. W., & Huh, J. B. (2013). The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 115(6), e24-e31. https://doi.org/10.1016/j.oooo.2011.10.040

The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant. / Kim, Jong Eun; Kang, Seong Su; Choi, Kyung Hee et al.
In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 115, No. 6, 06.2013, p. e24-e31.

Research output: Contribution to journal › Article › peer-review

Kim, JE, Kang, SS, Choi, KH, Shim, JS, Jeong, CM, Shin, SW & Huh, JB 2013, 'The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant', Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, vol. 115, no. 6, pp. e24-e31. https://doi.org/10.1016/j.oooo.2011.10.040

Kim JE, Kang SS, Choi KH, Shim JS, Jeong CM, Shin SW et al. The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2013 Jun;115(6):e24-e31. doi: 10.1016/j.oooo.2011.10.040

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title = "The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant",

abstract = "Objectives: The aim of this study was to evaluate the effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors (rhVEGFs) on vertical bone regeneration in the marginal portion of the peri-implant. Study Design: Supra-alveolar defects were created in 3 male beagle dogs. Each animal received 8 implants that were either coated with a single growth factor (rhBMP-2) or combined growth factors (rhBMP-2 + rhVEGF), or an anodized implant (the control group). The amount of the vertical bone regeneration, the bone-implant contact, and the intrathread bone density were investigated using histomorphometric analysis at 8 weeks. Results: The bone morphogenetic protein (BMP) group and the BMP-VEGF group showed vertical alveolar bone regeneration and enhanced bone-implant contact in the microthread compared with the control group (P <.05). Conclusions: Anodized implants coated with rhBMP-2 and rhBMP - 2 + rhVEGF can induce vertical alveolar bone regeneration, but the combined effect of rhBMP-2 and rhVEGF was not verified.",

author = "Kim, {Jong Eun} and Kang, {Seong Su} and Choi, {Kyung Hee} and Shim, {June Sung} and Jeong, {Chang Mo} and Shin, {Sang Wan} and Huh, {Jung Bo}",

note = "Funding Information: This work was supported by Pusan National University Research Grant 2011 . The implants and BMP-2 were kindly supplied by Cowellmedi Co. (Pusan, Korea). ",

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doi = "10.1016/j.oooo.2011.10.040",

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AU - Kim, Jong Eun

AU - Kang, Seong Su

AU - Choi, Kyung Hee

AU - Shim, June Sung

AU - Jeong, Chang Mo

AU - Shin, Sang Wan

AU - Huh, Jung Bo

N1 - Funding Information: This work was supported by Pusan National University Research Grant 2011 . The implants and BMP-2 were kindly supplied by Cowellmedi Co. (Pusan, Korea).

PY - 2013/6

Y1 - 2013/6

N2 - Objectives: The aim of this study was to evaluate the effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors (rhVEGFs) on vertical bone regeneration in the marginal portion of the peri-implant. Study Design: Supra-alveolar defects were created in 3 male beagle dogs. Each animal received 8 implants that were either coated with a single growth factor (rhBMP-2) or combined growth factors (rhBMP-2 + rhVEGF), or an anodized implant (the control group). The amount of the vertical bone regeneration, the bone-implant contact, and the intrathread bone density were investigated using histomorphometric analysis at 8 weeks. Results: The bone morphogenetic protein (BMP) group and the BMP-VEGF group showed vertical alveolar bone regeneration and enhanced bone-implant contact in the microthread compared with the control group (P <.05). Conclusions: Anodized implants coated with rhBMP-2 and rhBMP - 2 + rhVEGF can induce vertical alveolar bone regeneration, but the combined effect of rhBMP-2 and rhVEGF was not verified.

AB - Objectives: The aim of this study was to evaluate the effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors (rhVEGFs) on vertical bone regeneration in the marginal portion of the peri-implant. Study Design: Supra-alveolar defects were created in 3 male beagle dogs. Each animal received 8 implants that were either coated with a single growth factor (rhBMP-2) or combined growth factors (rhBMP-2 + rhVEGF), or an anodized implant (the control group). The amount of the vertical bone regeneration, the bone-implant contact, and the intrathread bone density were investigated using histomorphometric analysis at 8 weeks. Results: The bone morphogenetic protein (BMP) group and the BMP-VEGF group showed vertical alveolar bone regeneration and enhanced bone-implant contact in the microthread compared with the control group (P <.05). Conclusions: Anodized implants coated with rhBMP-2 and rhBMP - 2 + rhVEGF can induce vertical alveolar bone regeneration, but the combined effect of rhBMP-2 and rhVEGF was not verified.

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The effect of anodized implants coated with combined rhBMP-2 and recombinant human vascular endothelial growth factors on vertical bone regeneration in the marginal portion of the peri-implant

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