The effect of bioactive compounds in tea on lipid metabolism and obesity through regulation of peroxisome proliferator-activated receptors

Sung Joon Lee, Yaoyao Jia

    Research output: Contribution to journalReview articlepeer-review

    31 Citations (Scopus)

    Abstract

    Purpose of Review: The hypolipidemic and antiobesogenic effects of tea intake have been associated with bioactive compounds that regulate peroxisome proliferator-activated receptors (PPARs). This review describes the recent research on two of these compounds, (-)-epigallocatechin gallate (EGCG) and linalool. Recent Findings: Catechins (specifically EGCG) are key bioactive compounds found in tea, and a recent study has shown that linalool may also be an active tea compound. These compounds act on lipid metabolism by regulating PPAR subtypes. EGCG inhibits the key adipogenic transcription factor PPARγ while activating PPARα, whereas linalool is a PPARα agonist activating hepatic fatty acid uptake and subsequent oxidation to reduce plasma triglyceride levels. Summary: The collective activities of EGCG and linalool in tea may exert hypolipidemic and antiobesogenic effects by regulating PPARs. The research summarized in this review expands our understanding of the biological and physiological mechanisms of the bioactive compounds found in tea.

    Original languageEnglish
    Pages (from-to)3-9
    Number of pages7
    JournalCurrent Opinion in Lipidology
    Volume26
    Issue number1
    DOIs
    Publication statusPublished - 2015 Feb 13

    Bibliographical note

    Publisher Copyright:
    Copyright © 2015 Wolters Kluwer Health, Inc.

    Keywords

    • (-)-epigallocatechin gallate
    • linalool
    • lipid metabolism
    • peroxisome proliferator-activated receptors
    • tea

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Molecular Biology
    • Genetics
    • Nutrition and Dietetics
    • Cardiology and Cardiovascular Medicine
    • Cell Biology

    Fingerprint

    Dive into the research topics of 'The effect of bioactive compounds in tea on lipid metabolism and obesity through regulation of peroxisome proliferator-activated receptors'. Together they form a unique fingerprint.

    Cite this