The effect of calcium gluconate with natural extracts on skin toxicity of hydrofluoric acid

Jung Jin Shin, Hana Lee, Sang Hoon Jeong, Ji Hyun Kim, Myungjin Lee, Sang Wook Son

Research output: Contribution to journalArticlepeer-review


Backgrounds: Hydrofluoric acid (HF) is a highly corrosive acid. The conventional treatment for HF burn is topical application of calcium gluconate (CG). Our study aimed to assess the synergistic effects of natural extracts (Centella asiatica, Portulaca oleracea, and blueberry extracts) in combination with CG in healing HF induced burn wound. Methods: We investigated the effects of different topical CG formulations with natural extracts using cell proliferation assay, western blot, reverse transcription- polymerase chain reaction, human skin equivalent model (HSEM), and mouse model. Results: Topical CG formulations with natural extracts showed better recovery from HF burns shown by greater collagen expression in the dermal fibroblast model, HSEM and mouse model. Conclusion: Our study demonstrated that CG in combination with natural extracts show superior wound healing in treating HF burn compared to CG monotherapy.

Original languageEnglish
Pages (from-to)381-389
Number of pages9
JournalMolecular and Cellular Toxicology
Issue number4
Publication statusPublished - 2018 Oct 1

Bibliographical note

Funding Information:
Acknowledgements This study was supported by ‘‘The Business Foundation and Technology Development Project (S2258845)” of the Small and Medium Business Administration (SMBA) in South Korea.

Publisher Copyright:
© 2018, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Nature B.V.


  • Calcium gluconate
  • Human skin equivalent
  • Hydrofluoric acid
  • Natural extracts
  • Wound healing

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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