The effect of carboxymethyl-chitosan nanoparticles on proliferation of keloid fibroblast

Chao Feng; Xiguang Chen; Jing Zhang; Gangzheng Sun; Xiaojie Cheng; Zhiguo Wang; Hyun Jin Park

doi:10.1007/s11458-011-0229-6

The effect of carboxymethyl-chitosan nanoparticles on proliferation of keloid fibroblast

Chao Feng, Xiguang Chen, Jing Zhang, Gangzheng Sun, Xiaojie Cheng, Zhiguo Wang, Hyun Jin Park

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

In this study, different molecular weight (MW) carboxymethyl chitosans (CM-chitosan) nanoparticles were prepared by ionic gelification. The particle size of nanoparticles was around 180-250 nm by dynamic light scattering (DLS) and transmission electron microscope (TEM). With the increase of CM-chitosan nanoparticles concentration from 2 to 200 μg/mL, the growth inhibition effects on the keloid fibroblast increased. At the concentration of 100 μg/mL, CM-chitosan nanoparticles with MW6.3 kDa had a significant inhibitory effect (inhibition ratio 48.79%) of the proliferation of keloid fibroblast. Compared with CM-chitosan solution, the inhibition of CM-chitosan nanoparticles were lower in prior period and similar in later period. By analyzing the different effects of chitosan, CM-chitosan solution and CM-chitosan nanoparticles on proliferation of keloid fibroblast, we have found that the carboxylmethyl groups of CM-chitosan play an important role in inhibition of proliferation of keloid fibroblast.

Original language	English
Pages (from-to)	31-37
Number of pages	7
Journal	Frontiers of Chemistry in China
Volume	6
Issue number	1
DOIs	https://doi.org/10.1007/s11458-011-0229-6
Publication status	Published - 2011 Mar

Bibliographical note

Funding Information:
Acknowledgements This work was supported by the National Natural Science Foundation of China (Grant No. 81071274).

Keywords

carboxymethyl-chitosan
keloid fibroblast
nanoparticle
proliferation

ASJC Scopus subject areas

General Chemistry

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10.1007/s11458-011-0229-6

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title = "The effect of carboxymethyl-chitosan nanoparticles on proliferation of keloid fibroblast",

abstract = "In this study, different molecular weight (MW) carboxymethyl chitosans (CM-chitosan) nanoparticles were prepared by ionic gelification. The particle size of nanoparticles was around 180-250 nm by dynamic light scattering (DLS) and transmission electron microscope (TEM). With the increase of CM-chitosan nanoparticles concentration from 2 to 200 μg/mL, the growth inhibition effects on the keloid fibroblast increased. At the concentration of 100 μg/mL, CM-chitosan nanoparticles with MW6.3 kDa had a significant inhibitory effect (inhibition ratio 48.79%) of the proliferation of keloid fibroblast. Compared with CM-chitosan solution, the inhibition of CM-chitosan nanoparticles were lower in prior period and similar in later period. By analyzing the different effects of chitosan, CM-chitosan solution and CM-chitosan nanoparticles on proliferation of keloid fibroblast, we have found that the carboxylmethyl groups of CM-chitosan play an important role in inhibition of proliferation of keloid fibroblast.",

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author = "Chao Feng and Xiguang Chen and Jing Zhang and Gangzheng Sun and Xiaojie Cheng and Zhiguo Wang and Park, {Hyun Jin}",

note = "Funding Information: Acknowledgements This work was supported by the National Natural Science Foundation of China (Grant No. 81071274).",

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doi = "10.1007/s11458-011-0229-6",

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AU - Chen, Xiguang

AU - Zhang, Jing

AU - Sun, Gangzheng

AU - Cheng, Xiaojie

AU - Wang, Zhiguo

AU - Park, Hyun Jin

N1 - Funding Information: Acknowledgements This work was supported by the National Natural Science Foundation of China (Grant No. 81071274).

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N2 - In this study, different molecular weight (MW) carboxymethyl chitosans (CM-chitosan) nanoparticles were prepared by ionic gelification. The particle size of nanoparticles was around 180-250 nm by dynamic light scattering (DLS) and transmission electron microscope (TEM). With the increase of CM-chitosan nanoparticles concentration from 2 to 200 μg/mL, the growth inhibition effects on the keloid fibroblast increased. At the concentration of 100 μg/mL, CM-chitosan nanoparticles with MW6.3 kDa had a significant inhibitory effect (inhibition ratio 48.79%) of the proliferation of keloid fibroblast. Compared with CM-chitosan solution, the inhibition of CM-chitosan nanoparticles were lower in prior period and similar in later period. By analyzing the different effects of chitosan, CM-chitosan solution and CM-chitosan nanoparticles on proliferation of keloid fibroblast, we have found that the carboxylmethyl groups of CM-chitosan play an important role in inhibition of proliferation of keloid fibroblast.

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The effect of carboxymethyl-chitosan nanoparticles on proliferation of keloid fibroblast

Abstract

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Keywords

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