The effect of carboxymethyl-chitosan nanoparticles on proliferation of keloid fibroblast

Chao Feng, Xiguang Chen, Jing Zhang, Gangzheng Sun, Xiaojie Cheng, Zhiguo Wang, Hyun Jin Park

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


In this study, different molecular weight (MW) carboxymethyl chitosans (CM-chitosan) nanoparticles were prepared by ionic gelification. The particle size of nanoparticles was around 180-250 nm by dynamic light scattering (DLS) and transmission electron microscope (TEM). With the increase of CM-chitosan nanoparticles concentration from 2 to 200 μg/mL, the growth inhibition effects on the keloid fibroblast increased. At the concentration of 100 μg/mL, CM-chitosan nanoparticles with MW6.3 kDa had a significant inhibitory effect (inhibition ratio 48.79%) of the proliferation of keloid fibroblast. Compared with CM-chitosan solution, the inhibition of CM-chitosan nanoparticles were lower in prior period and similar in later period. By analyzing the different effects of chitosan, CM-chitosan solution and CM-chitosan nanoparticles on proliferation of keloid fibroblast, we have found that the carboxylmethyl groups of CM-chitosan play an important role in inhibition of proliferation of keloid fibroblast.

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalFrontiers of Chemistry in China
Issue number1
Publication statusPublished - 2011 Mar

Bibliographical note

Funding Information:
Acknowledgements This work was supported by the National Natural Science Foundation of China (Grant No. 81071274).


  • carboxymethyl-chitosan
  • keloid fibroblast
  • nanoparticle
  • proliferation

ASJC Scopus subject areas

  • General Chemistry


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