The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts

Xi Guang Chen; Zhen Wang; Wan Shun Liu; Hyun Jin Park

doi:10.1016/S0142-9612(02)00207-7

The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts

Xi Guang Chen, Zhen Wang, Wan Shun Liu, Hyun Jin Park

Research output: Contribution to journal › Article › peer-review

235 Citations (Scopus)

Abstract

In this study, different molecular weight CM-chitosans were prepared and the effects on the growth and collagen secretion of normal skin fibroblasts and keloid fibroblasts were investigated in vitro. CM-chitosan promoted the proliferation of the normal skin fibroblast significantly but inhibited the proliferation of keloid fibroblast. The higher CM-chitosan concentration had a higher initial effect and the lower CM-chitosan concentration had a longer affecting time to the normal skin fibroblast. The lower molecular weight CM-chitosan had significant twofold activities. The CM-chitosan could reduce the ratio of type I/III collagen in keloid fibroblast by inhibiting the secretion of collagen type I; and had no effect on the secretion of types I and III collagen in the normal skin fibroblast.

Original language	English
Pages (from-to)	4609-4614
Number of pages	6
Journal	Biomaterials
Volume	23
Issue number	23
DOIs	https://doi.org/10.1016/S0142-9612(02)00207-7
Publication status	Published - 2002 Dec

Bibliographical note

Funding Information:
We acknowledge the National Natural Science Foundation of China for the financial support.

Keywords

Biomaterial
CM-chitosan
Collagen
Fibroblast
Keloid
Proliferation

ASJC Scopus subject areas

Bioengineering
Ceramics and Composites
Biophysics
Biomaterials
Mechanics of Materials

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10.1016/S0142-9612(02)00207-7

Cite this

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title = "The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts",

abstract = "In this study, different molecular weight CM-chitosans were prepared and the effects on the growth and collagen secretion of normal skin fibroblasts and keloid fibroblasts were investigated in vitro. CM-chitosan promoted the proliferation of the normal skin fibroblast significantly but inhibited the proliferation of keloid fibroblast. The higher CM-chitosan concentration had a higher initial effect and the lower CM-chitosan concentration had a longer affecting time to the normal skin fibroblast. The lower molecular weight CM-chitosan had significant twofold activities. The CM-chitosan could reduce the ratio of type I/III collagen in keloid fibroblast by inhibiting the secretion of collagen type I; and had no effect on the secretion of types I and III collagen in the normal skin fibroblast.",

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author = "Chen, {Xi Guang} and Zhen Wang and Liu, {Wan Shun} and Park, {Hyun Jin}",

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AU - Chen, Xi Guang

AU - Wang, Zhen

AU - Liu, Wan Shun

AU - Park, Hyun Jin

N1 - Funding Information: We acknowledge the National Natural Science Foundation of China for the financial support.

PY - 2002/12

Y1 - 2002/12

N2 - In this study, different molecular weight CM-chitosans were prepared and the effects on the growth and collagen secretion of normal skin fibroblasts and keloid fibroblasts were investigated in vitro. CM-chitosan promoted the proliferation of the normal skin fibroblast significantly but inhibited the proliferation of keloid fibroblast. The higher CM-chitosan concentration had a higher initial effect and the lower CM-chitosan concentration had a longer affecting time to the normal skin fibroblast. The lower molecular weight CM-chitosan had significant twofold activities. The CM-chitosan could reduce the ratio of type I/III collagen in keloid fibroblast by inhibiting the secretion of collagen type I; and had no effect on the secretion of types I and III collagen in the normal skin fibroblast.

AB - In this study, different molecular weight CM-chitosans were prepared and the effects on the growth and collagen secretion of normal skin fibroblasts and keloid fibroblasts were investigated in vitro. CM-chitosan promoted the proliferation of the normal skin fibroblast significantly but inhibited the proliferation of keloid fibroblast. The higher CM-chitosan concentration had a higher initial effect and the lower CM-chitosan concentration had a longer affecting time to the normal skin fibroblast. The lower molecular weight CM-chitosan had significant twofold activities. The CM-chitosan could reduce the ratio of type I/III collagen in keloid fibroblast by inhibiting the secretion of collagen type I; and had no effect on the secretion of types I and III collagen in the normal skin fibroblast.

KW - Biomaterial

KW - CM-chitosan

KW - Collagen

KW - Fibroblast

KW - Keloid

KW - Proliferation

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The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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