The effect of photopigment bleaching on fundus autofluorescence in acute central serous chorioretinopathy

Kwang Eon Choi, Cheolmin Yun, Young Ho Kim, Seong Woo Kim, Jaeryung Oh, Kuhl Huh

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Purpose: To evaluate the effect of photobleaching on fundus autofluorescence (FAF) images in acute central serous chorioretinopathy. Methods: We obtained prephotobleaching and postphotobleaching images using an Optomap 200Tx, and photobleaching was induced with a Heidelberg Retina Angiograph 2. Degrees of photobleaching were assessed as grayscale values in Optomap images. Concordances among the three kinds of images were analyzed. Hyper-AF lesions in prephotobleaching images were classified as Type 1 (changed to normal-AF after photobleaching) and Type 2 (unchanged after photobleaching). The FAF composite patterns of central serous chorioretinopathy lesions were classified as diffuse or mottled. Initial and final best-corrected visual acuity, central retinal thickness, and disease duration were compared according to fovea FAF type. Results: Forty-one eyes of 41 patients were analyzed. The lesion brightness of postphotobleaching Optomap FAF showed greater concordance with Heidelberg Retina Angiograph 2 FAF (94.74%) than the prephotobleaching Optomap FAF (80.49%). Eyes with Type 1 fovea had greater initial and final best-corrected visual acuity (20/23 vs. 20/41, 20/21 vs. 20/32, P < 0.0001, P = 0.001, respectively) and shorter disease duration (19.68 ± 12.98 vs. 51.55 ± 44.98 days, P = 0.043) than those with Type 2 fovea. However, eyes with diffuse Type 2 fovea had only lower initial and final best-corrected visual acuity (20/23 vs. 20/45, 20/21 vs. 20/36, P < 0.0001, P < 0.0001, respectively) than those with Type 1 fovea. Conclusion: Understanding the photobleaching effect is necessary for the accurate interpretation of FAF images. Furthermore, comparing prephotobleaching and postphotobleaching FAF images may be helpful for estimation of lesion status in central serous chorioretinopathy.

Original languageEnglish
Pages (from-to)568-577
Number of pages10
Issue number3
Publication statusPublished - 2017
Externally publishedYes

Bibliographical note

Publisher Copyright:
© Copyright by Ophthalmic Communications Society, Inc.


  • Central serous chorioretinopathy
  • Fundus autofluorescence
  • Photobleaching
  • Photopigment bleaching

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'The effect of photopigment bleaching on fundus autofluorescence in acute central serous chorioretinopathy'. Together they form a unique fingerprint.

Cite this