TY - JOUR
T1 - The effect of pulsatile versus nonpulsatile blood flow on viscoelasticity and red blood cell aggregation in extracorporeal circulation
AU - Ahn, Chi Bum
AU - Kang, Yang Jun
AU - Kim, Myoung Gon
AU - Yang, Sung
AU - Lim, Choon Hak
AU - Son, Ho Sung
AU - Kim, Ji Sung
AU - Lee, So Young
AU - Son, Kuk Hui
AU - Sun, Kyung
N1 - Publisher Copyright:
© The Korean Society for Thoracic and Cardiovascular Surgery.
PY - 2016
Y1 - 2016
N2 - Extracorporeal circulation (ECC) can induce alterations in blood viscoelasticity and cause red blood cell (RBC) aggregation. In this study, the authors evaluated the effects of pump flow pulsatility on blood viscoelasticity and RBC aggregation. Methods: Mongrel dogs were randomly assigned to two groups: a nonpulsatile pump group (n=6) or a pulsatile pump group (n=6). After ECC was started at a pump flow rate of 80 mL/kg/min, cardiac fibrillation was induced. Blood sampling was performed before and at 1, 2, and 3 hours after ECC commencement. To eliminate bias induced by hematocrit and plasma, all blood samples were adjusted to a hematocrit of 45% using baseline plasma. Blood viscoelasticity, plasma viscosity, hematocrit, arterial blood gas analysis, central venous O2 saturation, and lactate were measured. Results: The blood viscosity and aggregation index decreased abruptly 1 hour after ECC and then remained low during ECC in both groups, but blood elasticity did not change during ECC. Blood viscosity, blood elasticity, plasma viscosity, and the aggregation index were not significantly different in the groups at any time. Hematocrit decreased abruptly 1 hour after ECC in both groups due to dilution by the priming solution used. Conclusion: After ECC, blood viscoelasticity and RBC aggregation were not different in the pulsatile and nonpulsatile groups in the adult dog model. Furthermore, pulsatile flow did not have a more harmful effect on blood viscoelasticity or RBC aggregation than nonpulsatile flow.
AB - Extracorporeal circulation (ECC) can induce alterations in blood viscoelasticity and cause red blood cell (RBC) aggregation. In this study, the authors evaluated the effects of pump flow pulsatility on blood viscoelasticity and RBC aggregation. Methods: Mongrel dogs were randomly assigned to two groups: a nonpulsatile pump group (n=6) or a pulsatile pump group (n=6). After ECC was started at a pump flow rate of 80 mL/kg/min, cardiac fibrillation was induced. Blood sampling was performed before and at 1, 2, and 3 hours after ECC commencement. To eliminate bias induced by hematocrit and plasma, all blood samples were adjusted to a hematocrit of 45% using baseline plasma. Blood viscoelasticity, plasma viscosity, hematocrit, arterial blood gas analysis, central venous O2 saturation, and lactate were measured. Results: The blood viscosity and aggregation index decreased abruptly 1 hour after ECC and then remained low during ECC in both groups, but blood elasticity did not change during ECC. Blood viscosity, blood elasticity, plasma viscosity, and the aggregation index were not significantly different in the groups at any time. Hematocrit decreased abruptly 1 hour after ECC in both groups due to dilution by the priming solution used. Conclusion: After ECC, blood viscoelasticity and RBC aggregation were not different in the pulsatile and nonpulsatile groups in the adult dog model. Furthermore, pulsatile flow did not have a more harmful effect on blood viscoelasticity or RBC aggregation than nonpulsatile flow.
KW - Blood
KW - Cardiopulmonary bypass
KW - Extracorporeal circulation
KW - Hematology
UR - http://www.scopus.com/inward/record.url?scp=84976905736&partnerID=8YFLogxK
U2 - 10.5090/kjtcs.2016.49.3.145
DO - 10.5090/kjtcs.2016.49.3.145
M3 - Article
AN - SCOPUS:84976905736
SN - 2233-601X
VL - 49
SP - 145
EP - 150
JO - Korean Journal of Thoracic and Cardiovascular Surgery
JF - Korean Journal of Thoracic and Cardiovascular Surgery
IS - 3
ER -