The effects of alcohol on visual evoked potential and multifocal electroretinography

Jee Taek Kim, Cheol Min Yun, Seong Woo Kim, Jaeryung Oh, Kuhl Huh

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


The aim of this study was to investigate the acute effects of ethanol administration on pattern-reversal visual evoked potential (VEP) and multifocal electroretinography (mfERG). Fifteen healthy subjects with no ocular or general disease were recruited. VEP (0.25° pattern sizes) and mfERG with 19 elements in two recording segments were performed before ethanol administration to obtain baseline for each participant. A few days later, the participants visited again for VEP and mfERG measurements after ethanol administration. Ethanol (0.75 g/kg) was administered orally over the course of 30 minutes. VEP and blood alcohol concentration were evaluated one hour after ethanol administration, and mfERG was conducted after pupil dilation. The Wilcoxon signed-rank test was used to compare parameter changes after randomized eye selection. The mean blood alcohol concentration was 0.034% ± 0.05% by volume. VEP revealed a P100 latency delay (109.4 ± 5.3; 113.1 ± 8.2; P = 0.008) after alcohol administration. The P1 implicit time of ring 1 on mfERG showed a trend of shortening after alcohol administration (37.9 ± 1.0; 37.2 ± 1.5; P = 0.048). However, the changes did not show statistical significance after Bonferroni correction. In conclusion, orally administrated ethanol (0.75 g/kg) appears to suppress the central nervous system, but it is not clear whether alcohol intake affects the retina.

Original languageEnglish
Pages (from-to)783-789
Number of pages7
JournalJournal of Korean medical science
Issue number5
Publication statusPublished - 2016 May 1
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2016 The Korean Academy of Medical Sciences.


  • Alcohol
  • Electroretinography
  • Visual evoked potential

ASJC Scopus subject areas

  • General Medicine


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