The effects of nanotopography and coculture systems to promote angiogenesis for wound repair

Tae Hee Kim, Soo Hyun Kim, Youngmee Jung

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)

    Abstract

    Insufficient angiogenesis in severe wounds delays wound repair because of a lack of blood supply to the wound site. Therefore, pro-angiogenic therapeutics may enhance wound repair. Many studies have investigated various physical and biochemical cues to improve angiogenesis, such as biocompatible materials, surface modifications, angiogenic factors and coculture systems using various cell types. However, the present capability to mimic the micro- and nanostructure of the natural microenvironment, particularly its porous, fibrous features, is limited. Nanotopography may represent a promising tool to overcome these limitations. Here, we discuss various approaches to the use of nanotopography to enhance angiogenesis and consider the combination of coculture systems with nanotopography to mimic the native environment for promotion of angiogenesis in wound healing and repair.

    Original languageEnglish
    Pages (from-to)2997-3007
    Number of pages11
    JournalNanomedicine
    Volume11
    Issue number22
    DOIs
    Publication statusPublished - 2016 Nov

    Bibliographical note

    Publisher Copyright:
    © 2016 Future Medicine Ltd.

    Keywords

    • angiogenesis
    • coculture system
    • endothelial cells
    • nanotopography
    • pericyte

    ASJC Scopus subject areas

    • Bioengineering
    • Development
    • Biomedical Engineering
    • General Materials Science
    • Medicine (miscellaneous)

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