The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women

Seo Yun Tong; Jong Min Lee; Eun Seop Song; Kwang Beom Lee; Mi Kyung Kim; Young Mi Yun; Jae Kwan Lee; Sung Kyong Son; Jung Pil Lee; Jae Hoon Kim; Soo Young Hur; Yong Il Kwon

doi:10.1007/s10552-009-9430-z

The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women

Seo Yun Tong, Jong Min Lee, Eun Seop Song, Kwang Beom Lee, Mi Kyung Kim, Young Mi Yun, Jae Kwan Lee, Sung Kyong Son, Jung Pil Lee, Jae Hoon Kim, Soo Young Hur, Yong Il Kwon

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

The purpose of the study was to investigate the association between cervical cancer risk and single-nucleotide polymorphisms (SNPs) in three one-carbon metabolism genes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) in Korean women. Twelve SNPs were identified in MTHFR, MTR, and MTRR in the 927 case-control samples, which included 165 cervical intraepithelial neoplasia 1 (CIN1), 167 cervical intraepithelial neoplasia 2 and 3 (CIN2/3), 155 cervical cancer patients, and 440 normal controls. The frequencies of the genotypes and haplotypes were assessed in the controls, CINs, and cervical cancers. Individual carriers of the variant allele C of MTHFR A1298C (rs1801131) had a 0.64-fold [95% confidence interval (CI): 0.42-0.98] decreased risk for CIN2/3 compared with common homozygotes. However, no significant association was found between most other variants and cervical cancer risk. The results also identified an increased CIN1 risk in carriers with at least one copy of haplotype 3 in the MTHFR gene (odds ratio, 1.88; 95% CI: 1.03-3.42). In conclusion, there was no significant association between most SNPs in MTHFR, MTR, or MTRR and the risk of CIN and cervical cancer in Korean women. In addition, there was no significant association of MTHFR haplotypes with risk of CIN2/3 and cervical cancer.

Original language	English
Pages (from-to)	23-30
Number of pages	8
Journal	Cancer Causes and Control
Volume	21
Issue number	1
DOIs	https://doi.org/10.1007/s10552-009-9430-z
Publication status	Published - 2010 Jan
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgment This work was supported in part by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MOST) (R01-2006-000-10621-0) and by a Korean Research Foundation grant (2005-C00517).

Keywords

Cervical cancer
Cervical intraepithelial neoplasia
Genetic polymorphisms
Methionine synthase
Methionine synthase reductase
Methylenetetrahydrofolate reductase

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10552-009-9430-z

Fingerprint

Dive into the research topics of 'The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women'. Together they form a unique fingerprint.

Cite this

Tong, S. Y., Lee, J. M., Song, E. S., Lee, K. B., Kim, M. K., Yun, Y. M., Lee, J. K., Son, S. K., Lee, J. P., Kim, J. H., Hur, S. Y., & Kwon, Y. I. (2010). The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women. Cancer Causes and Control, 21(1), 23-30. https://doi.org/10.1007/s10552-009-9430-z

The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women. / Tong, Seo Yun; Lee, Jong Min; Song, Eun Seop et al.
In: Cancer Causes and Control, Vol. 21, No. 1, 01.2010, p. 23-30.

Research output: Contribution to journal › Article › peer-review

Tong, SY, Lee, JM, Song, ES, Lee, KB, Kim, MK, Yun, YM, Lee, JK, Son, SK, Lee, JP, Kim, JH, Hur, SY & Kwon, YI 2010, 'The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women', Cancer Causes and Control, vol. 21, no. 1, pp. 23-30. https://doi.org/10.1007/s10552-009-9430-z

@article{47f8f8b183e842eb8c4c5ce213c0a78c,

title = "The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women",

abstract = "The purpose of the study was to investigate the association between cervical cancer risk and single-nucleotide polymorphisms (SNPs) in three one-carbon metabolism genes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) in Korean women. Twelve SNPs were identified in MTHFR, MTR, and MTRR in the 927 case-control samples, which included 165 cervical intraepithelial neoplasia 1 (CIN1), 167 cervical intraepithelial neoplasia 2 and 3 (CIN2/3), 155 cervical cancer patients, and 440 normal controls. The frequencies of the genotypes and haplotypes were assessed in the controls, CINs, and cervical cancers. Individual carriers of the variant allele C of MTHFR A1298C (rs1801131) had a 0.64-fold [95% confidence interval (CI): 0.42-0.98] decreased risk for CIN2/3 compared with common homozygotes. However, no significant association was found between most other variants and cervical cancer risk. The results also identified an increased CIN1 risk in carriers with at least one copy of haplotype 3 in the MTHFR gene (odds ratio, 1.88; 95% CI: 1.03-3.42). In conclusion, there was no significant association between most SNPs in MTHFR, MTR, or MTRR and the risk of CIN and cervical cancer in Korean women. In addition, there was no significant association of MTHFR haplotypes with risk of CIN2/3 and cervical cancer.",

keywords = "Cervical cancer, Cervical intraepithelial neoplasia, Genetic polymorphisms, Methionine synthase, Methionine synthase reductase, Methylenetetrahydrofolate reductase",

author = "Tong, {Seo Yun} and Lee, {Jong Min} and Song, {Eun Seop} and Lee, {Kwang Beom} and Kim, {Mi Kyung} and Yun, {Young Mi} and Lee, {Jae Kwan} and Son, {Sung Kyong} and Lee, {Jung Pil} and Kim, {Jae Hoon} and Hur, {Soo Young} and Kwon, {Yong Il}",

note = "Funding Information: Acknowledgment This work was supported in part by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MOST) (R01-2006-000-10621-0) and by a Korean Research Foundation grant (2005-C00517).",

year = "2010",

month = jan,

doi = "10.1007/s10552-009-9430-z",

language = "English",

volume = "21",

pages = "23--30",

journal = "Cancer Causes and Control",

issn = "0957-5243",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "1",

}

TY - JOUR

T1 - The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women

AU - Tong, Seo Yun

AU - Lee, Jong Min

AU - Song, Eun Seop

AU - Lee, Kwang Beom

AU - Kim, Mi Kyung

AU - Yun, Young Mi

AU - Lee, Jae Kwan

AU - Son, Sung Kyong

AU - Lee, Jung Pil

AU - Kim, Jae Hoon

AU - Hur, Soo Young

AU - Kwon, Yong Il

N1 - Funding Information: Acknowledgment This work was supported in part by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MOST) (R01-2006-000-10621-0) and by a Korean Research Foundation grant (2005-C00517).

PY - 2010/1

Y1 - 2010/1

N2 - The purpose of the study was to investigate the association between cervical cancer risk and single-nucleotide polymorphisms (SNPs) in three one-carbon metabolism genes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) in Korean women. Twelve SNPs were identified in MTHFR, MTR, and MTRR in the 927 case-control samples, which included 165 cervical intraepithelial neoplasia 1 (CIN1), 167 cervical intraepithelial neoplasia 2 and 3 (CIN2/3), 155 cervical cancer patients, and 440 normal controls. The frequencies of the genotypes and haplotypes were assessed in the controls, CINs, and cervical cancers. Individual carriers of the variant allele C of MTHFR A1298C (rs1801131) had a 0.64-fold [95% confidence interval (CI): 0.42-0.98] decreased risk for CIN2/3 compared with common homozygotes. However, no significant association was found between most other variants and cervical cancer risk. The results also identified an increased CIN1 risk in carriers with at least one copy of haplotype 3 in the MTHFR gene (odds ratio, 1.88; 95% CI: 1.03-3.42). In conclusion, there was no significant association between most SNPs in MTHFR, MTR, or MTRR and the risk of CIN and cervical cancer in Korean women. In addition, there was no significant association of MTHFR haplotypes with risk of CIN2/3 and cervical cancer.

AB - The purpose of the study was to investigate the association between cervical cancer risk and single-nucleotide polymorphisms (SNPs) in three one-carbon metabolism genes, methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) in Korean women. Twelve SNPs were identified in MTHFR, MTR, and MTRR in the 927 case-control samples, which included 165 cervical intraepithelial neoplasia 1 (CIN1), 167 cervical intraepithelial neoplasia 2 and 3 (CIN2/3), 155 cervical cancer patients, and 440 normal controls. The frequencies of the genotypes and haplotypes were assessed in the controls, CINs, and cervical cancers. Individual carriers of the variant allele C of MTHFR A1298C (rs1801131) had a 0.64-fold [95% confidence interval (CI): 0.42-0.98] decreased risk for CIN2/3 compared with common homozygotes. However, no significant association was found between most other variants and cervical cancer risk. The results also identified an increased CIN1 risk in carriers with at least one copy of haplotype 3 in the MTHFR gene (odds ratio, 1.88; 95% CI: 1.03-3.42). In conclusion, there was no significant association between most SNPs in MTHFR, MTR, or MTRR and the risk of CIN and cervical cancer in Korean women. In addition, there was no significant association of MTHFR haplotypes with risk of CIN2/3 and cervical cancer.

KW - Cervical cancer

KW - Cervical intraepithelial neoplasia

KW - Genetic polymorphisms

KW - Methionine synthase

KW - Methionine synthase reductase

KW - Methylenetetrahydrofolate reductase

UR - http://www.scopus.com/inward/record.url?scp=74149088732&partnerID=8YFLogxK

U2 - 10.1007/s10552-009-9430-z

DO - 10.1007/s10552-009-9430-z

M3 - Article

C2 - 19760026

AN - SCOPUS:74149088732

SN - 0957-5243

VL - 21

SP - 23

EP - 30

JO - Cancer Causes and Control

JF - Cancer Causes and Control

IS - 1

ER -

The effects of polymorphisms in methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and methionine synthase reductase (MTRR) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this