The efficacy of transdermal fentanyl for pain relief after endoscopic submucosal dissection: A prospective, randomised controlled trial

Hyuk Soon Choi, Kyoung Oh Kim, Hoon Jai Chun, Bora Keum, Yeon Seok Seo, Yong Sik Kim, Yoon Tae Jeen, Soon Ho Um, Hong Sik Lee, Chang Duck Kim, Ho Sang Ryu

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Objective: Epigastric pain management following endoscopic submucosal dissection is an important consideration. This study aimed to investigate the utility and safety of fentanyl patches for pain relief after the procedure. Methods: Patients who were scheduled to undergo endoscopic submucosal dissection were prospectively randomised to either a transdermal fentanyl patch group or a placebo control group. An additional pethidine was intravenously administered when pain developed and a numerical rating scale was used to evaluate both pre- and post-procedural pain. Results: One hundred and ten patients were randomly assigned to receive either a 12. mcg/h fentanyl patch or a control patch on the night before the procedure. The fentanyl patch group had significantly lower pain scores immediately following the procedure (mean, 5.17 vs. 4.26, p = 0.030). Maximal pain scores during the first 24. h (5.43 vs. 4.46, p = 0.038) and pain scores on the day after the procedure (2.98 vs. 1.20, p<0.001) were also lower in the fentanyl patch group. In addition, the fentanyl patch group required a significantly lower dose of pethidine for pain management (24.54 vs. 11.25, p = 0.004). Conclusions: The application of a transdermal fentanyl patch is an effective, convenient, and safe method to control epigastric pain after endoscopic submucosal dissection.

Original languageEnglish
Pages (from-to)925-929
Number of pages5
JournalDigestive and Liver Disease
Volume44
Issue number11
DOIs
Publication statusPublished - 2012 Nov
Externally publishedYes

Bibliographical note

Funding Information:
Funding for this work was provided by the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea ( A111182 ) and Grant of Korea University .

Keywords

  • Endoscopic submucosal dissection
  • Fentanyl patch
  • Pain

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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