The EPR effect in cancer therapy

Ji Young Yhee; Sejin Son; Sohee Son; Min Kyung Joo; Ick Chan Kwon

doi:10.1007/978-1-4614-7876-8_23

The EPR effect in cancer therapy

Ji Young Yhee
, Sejin Son
, Sohee Son
, Min Kyung Joo
, Ick Chan Kwon^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter

46 Citations (Scopus)

Abstract

The enhanced permeability and retention (EPR) effect is the property which small sized nanoparticles and macromolecular drugs can accumulate more in tumor than in normal tissues. The EPR effect is generally due to the larger pore size of neo-vasculatures and poor lymphatic clearance of tumors, and it is strongly influenced by the size of small molecules including nanoparticles. The EPR effect has been considered as an alternative method for delivery of conventional anticancer drugs, and favorable bio-distribution of cancer therapeutic nanoparticles in blood would be considered to achieve a high level of accumulation in solid tumors. Based on the EPR concept, a variety of drugs in nano-carrier systems have been developed for cancer therapy. In this chapter, current progress and good examples for EPR effect-utilized anticancer therapy are reviewed.

Original language	English
Title of host publication	Cancer Targeted Drug Delivery
Subtitle of host publication	An Elusive Dream
Publisher	Springer New York
Pages	621-632
Number of pages	12
Volume	9781461478768
ISBN (Electronic)	9781461478768
ISBN (Print)	1461478758, 9781461478751
DOIs	https://doi.org/10.1007/978-1-4614-7876-8_23
Publication status	Published - 2013 Jul 1
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

General Medicine

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10.1007/978-1-4614-7876-8_23

Cite this

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AU - Yhee, Ji Young

AU - Son, Sejin

AU - Son, Sohee

AU - Joo, Min Kyung

AU - Kwon, Ick Chan

PY - 2013/7/1

Y1 - 2013/7/1

N2 - The enhanced permeability and retention (EPR) effect is the property which small sized nanoparticles and macromolecular drugs can accumulate more in tumor than in normal tissues. The EPR effect is generally due to the larger pore size of neo-vasculatures and poor lymphatic clearance of tumors, and it is strongly influenced by the size of small molecules including nanoparticles. The EPR effect has been considered as an alternative method for delivery of conventional anticancer drugs, and favorable bio-distribution of cancer therapeutic nanoparticles in blood would be considered to achieve a high level of accumulation in solid tumors. Based on the EPR concept, a variety of drugs in nano-carrier systems have been developed for cancer therapy. In this chapter, current progress and good examples for EPR effect-utilized anticancer therapy are reviewed.

AB - The enhanced permeability and retention (EPR) effect is the property which small sized nanoparticles and macromolecular drugs can accumulate more in tumor than in normal tissues. The EPR effect is generally due to the larger pore size of neo-vasculatures and poor lymphatic clearance of tumors, and it is strongly influenced by the size of small molecules including nanoparticles. The EPR effect has been considered as an alternative method for delivery of conventional anticancer drugs, and favorable bio-distribution of cancer therapeutic nanoparticles in blood would be considered to achieve a high level of accumulation in solid tumors. Based on the EPR concept, a variety of drugs in nano-carrier systems have been developed for cancer therapy. In this chapter, current progress and good examples for EPR effect-utilized anticancer therapy are reviewed.

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M3 - Chapter

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VL - 9781461478768

SP - 621

EP - 632

BT - Cancer Targeted Drug Delivery

PB - Springer New York

ER -

The EPR effect in cancer therapy

Abstract

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ASJC Scopus subject areas

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