TY - JOUR
T1 - The first attempt at continuous-mode separation of racemic and meso-2,3-butanediol with high purities using a simulated-moving-bed process
AU - Lee, Chung Gi
AU - Song, Ye Jin
AU - Lee, Ki Bong
AU - Mun, Sungyong
N1 - Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (grant number NRF- 2015R1A2A2A01003455 ). Also, it was partially supported by the Advanced Biomass R&D Center (ABC) of Global Frontier Project funded by the Ministry of Science and ICT (ABC-2010-0029728).
Publisher Copyright:
© 2019 The Korean Society of Industrial and Engineering Chemistry
PY - 2019/12/25
Y1 - 2019/12/25
N2 - To maximize the industrial value of biologically produced 2,3-butanediol (BD), it is essential to separate BD into its stereoisomeric fractions, meso-BD and racemic-BD. To address such issue, a highly efficient BD-isomer separation process based on a simulated-moving-bed (SMB) mode was developed in this study. As a first step for this task, the competitive adsorption behaviors of meso-BD and racemic-BD on a properly selected adsorbent were investigated, and their relevant isotherm parameters were determined using inverse method. The determined isotherm parameters were then applied to the design of the BD-isomer separation process based on an SMB mode, which was carried out in such a way that both BD isomers could be separated with high purities and little losses in a continuous countercurrent mode. The performance of the designed SMB process for the targeted separation was experimentally investigated. It was confirmed from the experimental results that the BD-isomer separation SMB process, which was developed in this study for the first time, could be effective in the continuous-mode separation of meso-BD and racemic-BD with the purities higher than 99.9% and 97% respectively while maintaining their losses below 1%. The results of this study are expected to pave the way for establishing a highly economical process for a large-scale production of meso-BD and racemic-BD with high purities.
AB - To maximize the industrial value of biologically produced 2,3-butanediol (BD), it is essential to separate BD into its stereoisomeric fractions, meso-BD and racemic-BD. To address such issue, a highly efficient BD-isomer separation process based on a simulated-moving-bed (SMB) mode was developed in this study. As a first step for this task, the competitive adsorption behaviors of meso-BD and racemic-BD on a properly selected adsorbent were investigated, and their relevant isotherm parameters were determined using inverse method. The determined isotherm parameters were then applied to the design of the BD-isomer separation process based on an SMB mode, which was carried out in such a way that both BD isomers could be separated with high purities and little losses in a continuous countercurrent mode. The performance of the designed SMB process for the targeted separation was experimentally investigated. It was confirmed from the experimental results that the BD-isomer separation SMB process, which was developed in this study for the first time, could be effective in the continuous-mode separation of meso-BD and racemic-BD with the purities higher than 99.9% and 97% respectively while maintaining their losses below 1%. The results of this study are expected to pave the way for establishing a highly economical process for a large-scale production of meso-BD and racemic-BD with high purities.
KW - 2,3-Butanediol isomers
KW - Continuous separation
KW - Meso-2,3-Butanediol
KW - Process design
KW - Simulated moving bed
UR - http://www.scopus.com/inward/record.url?scp=85071476886&partnerID=8YFLogxK
U2 - 10.1016/j.jiec.2019.08.046
DO - 10.1016/j.jiec.2019.08.046
M3 - Article
AN - SCOPUS:85071476886
SN - 1226-086X
VL - 80
SP - 677
EP - 685
JO - Journal of Industrial and Engineering Chemistry
JF - Journal of Industrial and Engineering Chemistry
ER -