The flavonoid morin alleviates nuclear deformation in aged cells by disrupting progerin-lamin A/C binding

Jinsook Ahn; Tae Gyun Woo; So mi Kang; Inseong Jo; Jae Sung Woo; Bum Joon Park; Nam Chul Ha

doi:10.1016/j.jff.2020.104331

The flavonoid morin alleviates nuclear deformation in aged cells by disrupting progerin-lamin A/C binding

Jinsook Ahn, Tae Gyun Woo, So mi Kang, Inseong Jo, Jae Sung Woo, Bum Joon Park, Nam Chul Ha

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Nuclear lamin A/C plays an important role in maintaining the nuclear envelope structure. Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a silent mutation in the lamin A/C gene, leading to the production of a C-terminally truncated protein (progerin). A deformed nuclear shape is a hallmark of HGPS cells, which observed in normal aged cells. A recent study has found that progerin can directly interact with lamin A/C, which leads to nuclear deformation. In this study, we identified natural compounds that can disrupt this progerin-mediated interaction. Similar to the synthetic compound JH4, morin disrupted this progerin-mediated interaction. Treatment with 20 μM morin ameliorated nuclear deformation by more than 50% in progerin-expressing cells. As morin is a naturally occurring substance with anti-oxidative activity, it may be developed as a functional food to improve the lifespan and health of both HGPS patients and normal aging individuals.

Original language	English
Article number	104331
Journal	Journal of Functional Foods
Volume	77
DOIs	https://doi.org/10.1016/j.jff.2020.104331
Publication status	Published - 2021 Feb

Bibliographical note

Funding Information:
This study was supported by grants from the National Research Foundation of Korea (2019R1A2C208513512). In addition, this study was supported by the Basic Research Program through the National Research Foundation of Korea (NRF) funded by the MSIT (2020R1A4A101932211).

Publisher Copyright:
© 2020 The Authors

Keywords

Anti-aging
Hutchinson-Gilford progeria syndrome
Morin
Nuclear lamin A/C
Premature aging syndrome
Progerin

ASJC Scopus subject areas

Food Science
Nutrition and Dietetics
Medicine (miscellaneous)

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10.1016/j.jff.2020.104331

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title = "The flavonoid morin alleviates nuclear deformation in aged cells by disrupting progerin-lamin A/C binding",

abstract = "Nuclear lamin A/C plays an important role in maintaining the nuclear envelope structure. Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a silent mutation in the lamin A/C gene, leading to the production of a C-terminally truncated protein (progerin). A deformed nuclear shape is a hallmark of HGPS cells, which observed in normal aged cells. A recent study has found that progerin can directly interact with lamin A/C, which leads to nuclear deformation. In this study, we identified natural compounds that can disrupt this progerin-mediated interaction. Similar to the synthetic compound JH4, morin disrupted this progerin-mediated interaction. Treatment with 20 μM morin ameliorated nuclear deformation by more than 50% in progerin-expressing cells. As morin is a naturally occurring substance with anti-oxidative activity, it may be developed as a functional food to improve the lifespan and health of both HGPS patients and normal aging individuals.",

keywords = "Anti-aging, Hutchinson-Gilford progeria syndrome, Morin, Nuclear lamin A/C, Premature aging syndrome, Progerin",

author = "Jinsook Ahn and Woo, {Tae Gyun} and Kang, {So mi} and Inseong Jo and Woo, {Jae Sung} and Park, {Bum Joon} and Ha, {Nam Chul}",

note = "Funding Information: This study was supported by grants from the National Research Foundation of Korea (2019R1A2C208513512). In addition, this study was supported by the Basic Research Program through the National Research Foundation of Korea (NRF) funded by the MSIT (2020R1A4A101932211). Publisher Copyright: {\textcopyright} 2020 The Authors",

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doi = "10.1016/j.jff.2020.104331",

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volume = "77",

journal = "Journal of Functional Foods",

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AU - Ahn, Jinsook

AU - Woo, Tae Gyun

AU - Kang, So mi

AU - Jo, Inseong

AU - Woo, Jae Sung

AU - Park, Bum Joon

AU - Ha, Nam Chul

N1 - Funding Information: This study was supported by grants from the National Research Foundation of Korea (2019R1A2C208513512). In addition, this study was supported by the Basic Research Program through the National Research Foundation of Korea (NRF) funded by the MSIT (2020R1A4A101932211). Publisher Copyright: © 2020 The Authors

PY - 2021/2

Y1 - 2021/2

N2 - Nuclear lamin A/C plays an important role in maintaining the nuclear envelope structure. Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a silent mutation in the lamin A/C gene, leading to the production of a C-terminally truncated protein (progerin). A deformed nuclear shape is a hallmark of HGPS cells, which observed in normal aged cells. A recent study has found that progerin can directly interact with lamin A/C, which leads to nuclear deformation. In this study, we identified natural compounds that can disrupt this progerin-mediated interaction. Similar to the synthetic compound JH4, morin disrupted this progerin-mediated interaction. Treatment with 20 μM morin ameliorated nuclear deformation by more than 50% in progerin-expressing cells. As morin is a naturally occurring substance with anti-oxidative activity, it may be developed as a functional food to improve the lifespan and health of both HGPS patients and normal aging individuals.

AB - Nuclear lamin A/C plays an important role in maintaining the nuclear envelope structure. Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a silent mutation in the lamin A/C gene, leading to the production of a C-terminally truncated protein (progerin). A deformed nuclear shape is a hallmark of HGPS cells, which observed in normal aged cells. A recent study has found that progerin can directly interact with lamin A/C, which leads to nuclear deformation. In this study, we identified natural compounds that can disrupt this progerin-mediated interaction. Similar to the synthetic compound JH4, morin disrupted this progerin-mediated interaction. Treatment with 20 μM morin ameliorated nuclear deformation by more than 50% in progerin-expressing cells. As morin is a naturally occurring substance with anti-oxidative activity, it may be developed as a functional food to improve the lifespan and health of both HGPS patients and normal aging individuals.

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The flavonoid morin alleviates nuclear deformation in aged cells by disrupting progerin-lamin A/C binding

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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