Nuclear lamin A/C plays an important role in maintaining the nuclear envelope structure. Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a silent mutation in the lamin A/C gene, leading to the production of a C-terminally truncated protein (progerin). A deformed nuclear shape is a hallmark of HGPS cells, which observed in normal aged cells. A recent study has found that progerin can directly interact with lamin A/C, which leads to nuclear deformation. In this study, we identified natural compounds that can disrupt this progerin-mediated interaction. Similar to the synthetic compound JH4, morin disrupted this progerin-mediated interaction. Treatment with 20 μM morin ameliorated nuclear deformation by more than 50% in progerin-expressing cells. As morin is a naturally occurring substance with anti-oxidative activity, it may be developed as a functional food to improve the lifespan and health of both HGPS patients and normal aging individuals.
Bibliographical noteFunding Information:
This study was supported by grants from the National Research Foundation of Korea (2019R1A2C208513512). In addition, this study was supported by the Basic Research Program through the National Research Foundation of Korea (NRF) funded by the MSIT (2020R1A4A101932211).
© 2020 The Authors
- Hutchinson-Gilford progeria syndrome
- Nuclear lamin A/C
- Premature aging syndrome
ASJC Scopus subject areas
- Food Science
- Nutrition and Dietetics
- Medicine (miscellaneous)