TY - JOUR
T1 - The genetic polymorphisms of HER-2 and the risk of lung cancer in a Korean population
AU - Jo, Uk
AU - Han, Sle Gi Lo
AU - Seo, Jae Hong
AU - Park, Kyong Hwa
AU - Lee, Jae Won
AU - Lee, Hyo Jung
AU - Ryu, Jeong Seon
AU - Kim, Yeul Hong
N1 - Funding Information:
We thank Elizabeth K Chu for her help for the preparation of this manuscript. This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health &Welfare, Republic of Korea (A010250), Dr. Jae Won Lee and Hyo Jung Lee were supported by the grant (M10740002-07N4003-00200) from National R&D program of Ministry of Science and Technology(MOST) and Korea Science and Engineering Foundation (KOSEF)
PY - 2008/12/4
Y1 - 2008/12/4
N2 - Background: Human Epidermal Growth Factor Receptor 2 (HER-2; also known as erbB-2 or neu), a proto-oncogene of the receptor tyrosine kinase superfamily, has been associated with carcinogenesis and prognosis of human cancers, acting as a binding partner of other epidermal growth factor receptor (EGFR) family in the activation of EGFR signaling. Amplification of the HER-2 gene has been reported in lung cancer, where it has been associated with poor prognosis. In this study, we investigated whether the four polymorphisms (-3444C> T, -1985 G > T, I655A A> G and P1170A C> G) of the HER-2 gene are associated with the risk of lung cancer in Korean populations. Methods: The frequencies of 4 polymorphisms of the HER-2 gene were examined by the polymerase chain reaction-restriction fragment length polymorphism or the single-nucleotide polymorphism-identification technology assay in the 407 lung cancer patients and 407 healthy controls. Results: The frequencies of the 4 polymorphisms were not significantly different between patient and control groups in overall subjects. However, in the subgroup analysis, the 3 single nucleotide polymorphisms (-3444C> T, -1985G> T and P1170A C>G) showed statistically significant differences in the subgroups of females, non-smokers, and non-drinkers (p < 0.05). Additionally, we found the association between the risk of lung cancer and the polymorphisms of HER-2 gene in non-smoker subgroups with adenocarcinoma (p < 0.05). Conclusion: Our results suggest that the polymorphisms of the HER-2 gene are associated with an increased susceptibility to lung cancer in females, non-smokers and non-drinkers subgroups in the Korean population.
AB - Background: Human Epidermal Growth Factor Receptor 2 (HER-2; also known as erbB-2 or neu), a proto-oncogene of the receptor tyrosine kinase superfamily, has been associated with carcinogenesis and prognosis of human cancers, acting as a binding partner of other epidermal growth factor receptor (EGFR) family in the activation of EGFR signaling. Amplification of the HER-2 gene has been reported in lung cancer, where it has been associated with poor prognosis. In this study, we investigated whether the four polymorphisms (-3444C> T, -1985 G > T, I655A A> G and P1170A C> G) of the HER-2 gene are associated with the risk of lung cancer in Korean populations. Methods: The frequencies of 4 polymorphisms of the HER-2 gene were examined by the polymerase chain reaction-restriction fragment length polymorphism or the single-nucleotide polymorphism-identification technology assay in the 407 lung cancer patients and 407 healthy controls. Results: The frequencies of the 4 polymorphisms were not significantly different between patient and control groups in overall subjects. However, in the subgroup analysis, the 3 single nucleotide polymorphisms (-3444C> T, -1985G> T and P1170A C>G) showed statistically significant differences in the subgroups of females, non-smokers, and non-drinkers (p < 0.05). Additionally, we found the association between the risk of lung cancer and the polymorphisms of HER-2 gene in non-smoker subgroups with adenocarcinoma (p < 0.05). Conclusion: Our results suggest that the polymorphisms of the HER-2 gene are associated with an increased susceptibility to lung cancer in females, non-smokers and non-drinkers subgroups in the Korean population.
UR - http://www.scopus.com/inward/record.url?scp=63549089818&partnerID=8YFLogxK
U2 - 10.1186/1471-2407-8-359
DO - 10.1186/1471-2407-8-359
M3 - Article
C2 - 19055823
AN - SCOPUS:63549089818
SN - 1471-2407
VL - 8
JO - BMC Cancer
JF - BMC Cancer
M1 - 359
ER -