The Impact of Extracorporeal Shock Wave Therapy on Microcirculation in Diabetic Feet: A Pilot Study

Jong Phil Yang; Ye Na Lee; Ji Won Son; Seung Kyu Han

doi:10.1097/01.ASW.0000604180.54706.b2

The Impact of Extracorporeal Shock Wave Therapy on Microcirculation in Diabetic Feet: A Pilot Study

Jong Phil Yang, Ye Na Lee, Ji Won Son, Seung Kyu Han

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

BACKGROUND Patients with diabetic foot commonly experience vascular insufficiency and compromised tissue perfusion. Extracorporeal shockwave therapy (ESWT) reportedly promotes wound healing and angiogenesis, but clinical studies on the effect of ESWT on angiogenesis are scarce and the exact mechanism remains unclear. OBJECTIVE To investigate the effect of ESWT on cutaneous microcirculation in diabetic feet. METHODS Ten patients with diabetic feet received ESWT twice weekly for a total of six sessions. Transcutaneous partial oxygen pressure (Tcpo²) and cutaneous blood flow were measured before and after ESWT. MAIN RESULTS The treated feet showed statistically significant improvements in the mean Tcpo² (P <.01) and cutaneous blood flow level (P <.05) compared with control feet. In treated feet, Tcpo² increased by 19.6%, from 41.4 ± 9.9 to 49.5 ± 8.7 mm Hg (P <.05). In control feet, Tcpo² decreased by 11.6%, from 39.5 ± 14.0 to 34.9 ± 14.5 mm Hg (P =.059). The average cutaneous blood flow level of treated feet before ESWT was 36.9 ± 25.6, which increased to 48.3 ± 32.4 AU after ESWT (30.9% increase; P =.646). In control feet, the cutaneous blood flow level decreased from 80.5 ± 36.7 to 60.4 ± 38.8 AU, a decrease of 25.0% (P =.241). CONCLUSIONS These results demonstrate that ESWT may have beneficial effects on microcirculation in diabetic feet.

Original language	English
Pages (from-to)	563-567
Number of pages	5
Journal	Advances in Skin and Wound Care
Volume	32
Issue number	12
DOIs	https://doi.org/10.1097/01.ASW.0000604180.54706.b2
Publication status	Published - 2019 Dec 1

Bibliographical note

Funding Information:
In the Department of Plastic Surgery, Korea University College of Medicine, in Seoul, Korea, Jong-Phil Yang, MD, is a resident; Ye-Na Lee, MSc, RN, WCN, is a wound care nurse; Ji Won Son, RN, FKWA, is a wound care nurse; and Seung-Kyu Han, PhD, MD, is a professor. Acknowledgment: This study was supported by a grant from Sanuwave, Inc. The authors have disclosed no other financial relationships related to this article. Submitted October 30, 2018; accepted in revised form February 6, 2018.

Publisher Copyright:
© 2019 Wolters Kluwer Health, Inc. All rights reserved.

Keywords

blood flow
diabetic feet
extracorporeal shockwave therapy
microcirculation
perfusion
transcutaneous partial oxygen pressure

ASJC Scopus subject areas

Dermatology
Advanced and Specialised Nursing

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1097/01.ASW.0000604180.54706.b2

Cite this

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title = "The Impact of Extracorporeal Shock Wave Therapy on Microcirculation in Diabetic Feet: A Pilot Study",

abstract = "BACKGROUND Patients with diabetic foot commonly experience vascular insufficiency and compromised tissue perfusion. Extracorporeal shockwave therapy (ESWT) reportedly promotes wound healing and angiogenesis, but clinical studies on the effect of ESWT on angiogenesis are scarce and the exact mechanism remains unclear. OBJECTIVE To investigate the effect of ESWT on cutaneous microcirculation in diabetic feet. METHODS Ten patients with diabetic feet received ESWT twice weekly for a total of six sessions. Transcutaneous partial oxygen pressure (Tcpo2) and cutaneous blood flow were measured before and after ESWT. MAIN RESULTS The treated feet showed statistically significant improvements in the mean Tcpo2 (P <.01) and cutaneous blood flow level (P <.05) compared with control feet. In treated feet, Tcpo2 increased by 19.6%, from 41.4 ± 9.9 to 49.5 ± 8.7 mm Hg (P <.05). In control feet, Tcpo2 decreased by 11.6%, from 39.5 ± 14.0 to 34.9 ± 14.5 mm Hg (P =.059). The average cutaneous blood flow level of treated feet before ESWT was 36.9 ± 25.6, which increased to 48.3 ± 32.4 AU after ESWT (30.9% increase; P =.646). In control feet, the cutaneous blood flow level decreased from 80.5 ± 36.7 to 60.4 ± 38.8 AU, a decrease of 25.0% (P =.241). CONCLUSIONS These results demonstrate that ESWT may have beneficial effects on microcirculation in diabetic feet.",

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author = "Yang, {Jong Phil} and Lee, {Ye Na} and Son, {Ji Won} and Han, {Seung Kyu}",

note = "Funding Information: In the Department of Plastic Surgery, Korea University College of Medicine, in Seoul, Korea, Jong-Phil Yang, MD, is a resident; Ye-Na Lee, MSc, RN, WCN, is a wound care nurse; Ji Won Son, RN, FKWA, is a wound care nurse; and Seung-Kyu Han, PhD, MD, is a professor. Acknowledgment: This study was supported by a grant from Sanuwave, Inc. The authors have disclosed no other financial relationships related to this article. Submitted October 30, 2018; accepted in revised form February 6, 2018. Publisher Copyright: {\textcopyright} 2019 Wolters Kluwer Health, Inc. All rights reserved.",

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T1 - The Impact of Extracorporeal Shock Wave Therapy on Microcirculation in Diabetic Feet

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AU - Yang, Jong Phil

AU - Lee, Ye Na

AU - Son, Ji Won

AU - Han, Seung Kyu

N1 - Funding Information: In the Department of Plastic Surgery, Korea University College of Medicine, in Seoul, Korea, Jong-Phil Yang, MD, is a resident; Ye-Na Lee, MSc, RN, WCN, is a wound care nurse; Ji Won Son, RN, FKWA, is a wound care nurse; and Seung-Kyu Han, PhD, MD, is a professor. Acknowledgment: This study was supported by a grant from Sanuwave, Inc. The authors have disclosed no other financial relationships related to this article. Submitted October 30, 2018; accepted in revised form February 6, 2018. Publisher Copyright: © 2019 Wolters Kluwer Health, Inc. All rights reserved.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - BACKGROUND Patients with diabetic foot commonly experience vascular insufficiency and compromised tissue perfusion. Extracorporeal shockwave therapy (ESWT) reportedly promotes wound healing and angiogenesis, but clinical studies on the effect of ESWT on angiogenesis are scarce and the exact mechanism remains unclear. OBJECTIVE To investigate the effect of ESWT on cutaneous microcirculation in diabetic feet. METHODS Ten patients with diabetic feet received ESWT twice weekly for a total of six sessions. Transcutaneous partial oxygen pressure (Tcpo2) and cutaneous blood flow were measured before and after ESWT. MAIN RESULTS The treated feet showed statistically significant improvements in the mean Tcpo2 (P <.01) and cutaneous blood flow level (P <.05) compared with control feet. In treated feet, Tcpo2 increased by 19.6%, from 41.4 ± 9.9 to 49.5 ± 8.7 mm Hg (P <.05). In control feet, Tcpo2 decreased by 11.6%, from 39.5 ± 14.0 to 34.9 ± 14.5 mm Hg (P =.059). The average cutaneous blood flow level of treated feet before ESWT was 36.9 ± 25.6, which increased to 48.3 ± 32.4 AU after ESWT (30.9% increase; P =.646). In control feet, the cutaneous blood flow level decreased from 80.5 ± 36.7 to 60.4 ± 38.8 AU, a decrease of 25.0% (P =.241). CONCLUSIONS These results demonstrate that ESWT may have beneficial effects on microcirculation in diabetic feet.

AB - BACKGROUND Patients with diabetic foot commonly experience vascular insufficiency and compromised tissue perfusion. Extracorporeal shockwave therapy (ESWT) reportedly promotes wound healing and angiogenesis, but clinical studies on the effect of ESWT on angiogenesis are scarce and the exact mechanism remains unclear. OBJECTIVE To investigate the effect of ESWT on cutaneous microcirculation in diabetic feet. METHODS Ten patients with diabetic feet received ESWT twice weekly for a total of six sessions. Transcutaneous partial oxygen pressure (Tcpo2) and cutaneous blood flow were measured before and after ESWT. MAIN RESULTS The treated feet showed statistically significant improvements in the mean Tcpo2 (P <.01) and cutaneous blood flow level (P <.05) compared with control feet. In treated feet, Tcpo2 increased by 19.6%, from 41.4 ± 9.9 to 49.5 ± 8.7 mm Hg (P <.05). In control feet, Tcpo2 decreased by 11.6%, from 39.5 ± 14.0 to 34.9 ± 14.5 mm Hg (P =.059). The average cutaneous blood flow level of treated feet before ESWT was 36.9 ± 25.6, which increased to 48.3 ± 32.4 AU after ESWT (30.9% increase; P =.646). In control feet, the cutaneous blood flow level decreased from 80.5 ± 36.7 to 60.4 ± 38.8 AU, a decrease of 25.0% (P =.241). CONCLUSIONS These results demonstrate that ESWT may have beneficial effects on microcirculation in diabetic feet.

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KW - extracorporeal shockwave therapy

KW - microcirculation

KW - perfusion

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SN - 1527-7941

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JO - Advances in Skin and Wound Care

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ER -

The Impact of Extracorporeal Shock Wave Therapy on Microcirculation in Diabetic Feet: A Pilot Study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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