The Impact of Extracorporeal Shock Wave Therapy on Microcirculation in Diabetic Feet: A Pilot Study

Jong Phil Yang, Ye Na Lee, Ji Won Son, Seung Kyu Han

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    6 Citations (Scopus)


    BACKGROUND Patients with diabetic foot commonly experience vascular insufficiency and compromised tissue perfusion. Extracorporeal shockwave therapy (ESWT) reportedly promotes wound healing and angiogenesis, but clinical studies on the effect of ESWT on angiogenesis are scarce and the exact mechanism remains unclear. OBJECTIVE To investigate the effect of ESWT on cutaneous microcirculation in diabetic feet. METHODS Ten patients with diabetic feet received ESWT twice weekly for a total of six sessions. Transcutaneous partial oxygen pressure (Tcpo2) and cutaneous blood flow were measured before and after ESWT. MAIN RESULTS The treated feet showed statistically significant improvements in the mean Tcpo2 (P <.01) and cutaneous blood flow level (P <.05) compared with control feet. In treated feet, Tcpo2 increased by 19.6%, from 41.4 ± 9.9 to 49.5 ± 8.7 mm Hg (P <.05). In control feet, Tcpo2 decreased by 11.6%, from 39.5 ± 14.0 to 34.9 ± 14.5 mm Hg (P =.059). The average cutaneous blood flow level of treated feet before ESWT was 36.9 ± 25.6, which increased to 48.3 ± 32.4 AU after ESWT (30.9% increase; P =.646). In control feet, the cutaneous blood flow level decreased from 80.5 ± 36.7 to 60.4 ± 38.8 AU, a decrease of 25.0% (P =.241). CONCLUSIONS These results demonstrate that ESWT may have beneficial effects on microcirculation in diabetic feet.

    Original languageEnglish
    Pages (from-to)563-567
    Number of pages5
    JournalAdvances in Skin and Wound Care
    Issue number12
    Publication statusPublished - 2019 Dec 1

    Bibliographical note

    Funding Information:
    In the Department of Plastic Surgery, Korea University College of Medicine, in Seoul, Korea, Jong-Phil Yang, MD, is a resident; Ye-Na Lee, MSc, RN, WCN, is a wound care nurse; Ji Won Son, RN, FKWA, is a wound care nurse; and Seung-Kyu Han, PhD, MD, is a professor. Acknowledgment: This study was supported by a grant from Sanuwave, Inc. The authors have disclosed no other financial relationships related to this article. Submitted October 30, 2018; accepted in revised form February 6, 2018.

    Publisher Copyright:
    © 2019 Wolters Kluwer Health, Inc. All rights reserved.


    • blood flow
    • diabetic feet
    • extracorporeal shockwave therapy
    • microcirculation
    • perfusion
    • transcutaneous partial oxygen pressure

    ASJC Scopus subject areas

    • Dermatology
    • Advanced and Specialised Nursing


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