The impact of immobilization of BMP-2 on PDO membrane for bone regeneration

Ji Eun Kim, Eun Jung Lee, Hyoun Ee Kim, Young Hag Koh, Jun Hyeog Jang

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Poly(dioxanone) (PDO) is colorless, crystalline, a biodegradable synthetic polymers that is used for biomedical applications, such as surgical sutures, cardiovascular applications, orthopedics, and plastic surgery. Recently, bone morphogenetic protein-2 (BMP-2) is widely used for bone tissue engineering. For the first time we report here on the in vitro performance of an electrospun PDO membrane immobilized with BMP-2. Immobilized BMP-2 on PDO membrane enhanced ALPase activity, the osteogenic differentiation gene expressions as well as cell attachment, except cell proliferation when compared to that of PDO membrane alone. These results suggest that PDO membrane with BMP-2 is helpful to promote bone healing and regeneration.

Original languageEnglish
Pages (from-to)1488-1493
Number of pages6
JournalJournal of Biomedical Materials Research - Part A
Volume100 A
Issue number6
Publication statusPublished - 2012 Jun


  • biodegradation
  • bone
  • bone morphogenetic protein-2
  • in vitro
  • poly(dioxanone)

ASJC Scopus subject areas

  • Ceramics and Composites
  • Biomaterials
  • Biomedical Engineering
  • Metals and Alloys


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