The induction of BDNF and c-fos mRNA in the hippocampal formation after febrile seizures

Y. H. Kim; I. J. Rhyu; Kun Woo Park; Baik-Lin Eun; Y. I. Kim; H. K. Rha; D. S. Kim; Y. H. Jo; K. T. Whang; M. S. Kim

doi:10.1097/00001756-200110290-00020

The induction of BDNF and c-fos mRNA in the hippocampal formation after febrile seizures

Y. H. Kim, I. J. Rhyu, Kun Woo Park, Baik-Lin Eun, Y. I. Kim, H. K. Rha, D. S. Kim, Y. H. Jo, K. T. Whang, M. S. Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

In this study we investigated the expression of brain-derived neurotrophic factor (BDNF) and c-fos mRNA in the hippocampal formation after febrile seizures (FSs) with in situ hybridization histochemistry using riboprobes. The induction of BDNF mRNA was firstly observed in the dentate gyrus at 30 min after FSs. The expression in the dentate gyrus peaked at 3 h and returned to basal level at 24 h. It was also observed in the CA3 of hippocampus from 2 to 3 h. The induction of c-fos mRNA was observed in the dentate gyrus at 30min and 1 h. These observations suggest that BDNF and c-fos are the genes whose expression can be altered by FSs and might be related to pathologic alterations after FSs.

Original language	English
Pages (from-to)	3243-3246
Number of pages	4
Journal	Neuroreport
Volume	12
Issue number	15
DOIs	https://doi.org/10.1097/00001756-200110290-00020
Publication status	Published - 2001 Oct 29

Keywords

BDNF mRNA
C-fos mRNA
Dentate gyrus
Febrile seizure

ASJC Scopus subject areas

Neuroscience(all)

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10.1097/00001756-200110290-00020

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title = "The induction of BDNF and c-fos mRNA in the hippocampal formation after febrile seizures",

abstract = "In this study we investigated the expression of brain-derived neurotrophic factor (BDNF) and c-fos mRNA in the hippocampal formation after febrile seizures (FSs) with in situ hybridization histochemistry using riboprobes. The induction of BDNF mRNA was firstly observed in the dentate gyrus at 30 min after FSs. The expression in the dentate gyrus peaked at 3 h and returned to basal level at 24 h. It was also observed in the CA3 of hippocampus from 2 to 3 h. The induction of c-fos mRNA was observed in the dentate gyrus at 30min and 1 h. These observations suggest that BDNF and c-fos are the genes whose expression can be altered by FSs and might be related to pathologic alterations after FSs.",

keywords = "BDNF mRNA, C-fos mRNA, Dentate gyrus, Febrile seizure",

author = "Kim, {Y. H.} and Rhyu, {I. J.} and Park, {Kun Woo} and Baik-Lin Eun and Kim, {Y. I.} and Rha, {H. K.} and Kim, {D. S.} and Jo, {Y. H.} and Whang, {K. T.} and Kim, {M. S.}",

year = "2001",

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doi = "10.1097/00001756-200110290-00020",

language = "English",

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T1 - The induction of BDNF and c-fos mRNA in the hippocampal formation after febrile seizures

AU - Kim, Y. H.

AU - Rhyu, I. J.

AU - Park, Kun Woo

AU - Eun, Baik-Lin

AU - Kim, Y. I.

AU - Rha, H. K.

AU - Kim, D. S.

AU - Jo, Y. H.

AU - Whang, K. T.

AU - Kim, M. S.

PY - 2001/10/29

Y1 - 2001/10/29

N2 - In this study we investigated the expression of brain-derived neurotrophic factor (BDNF) and c-fos mRNA in the hippocampal formation after febrile seizures (FSs) with in situ hybridization histochemistry using riboprobes. The induction of BDNF mRNA was firstly observed in the dentate gyrus at 30 min after FSs. The expression in the dentate gyrus peaked at 3 h and returned to basal level at 24 h. It was also observed in the CA3 of hippocampus from 2 to 3 h. The induction of c-fos mRNA was observed in the dentate gyrus at 30min and 1 h. These observations suggest that BDNF and c-fos are the genes whose expression can be altered by FSs and might be related to pathologic alterations after FSs.

AB - In this study we investigated the expression of brain-derived neurotrophic factor (BDNF) and c-fos mRNA in the hippocampal formation after febrile seizures (FSs) with in situ hybridization histochemistry using riboprobes. The induction of BDNF mRNA was firstly observed in the dentate gyrus at 30 min after FSs. The expression in the dentate gyrus peaked at 3 h and returned to basal level at 24 h. It was also observed in the CA3 of hippocampus from 2 to 3 h. The induction of c-fos mRNA was observed in the dentate gyrus at 30min and 1 h. These observations suggest that BDNF and c-fos are the genes whose expression can be altered by FSs and might be related to pathologic alterations after FSs.

KW - BDNF mRNA

KW - C-fos mRNA

KW - Dentate gyrus

KW - Febrile seizure

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U2 - 10.1097/00001756-200110290-00020

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AN - SCOPUS:0035968930

SN - 0959-4965

VL - 12

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EP - 3246

JO - NeuroReport

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IS - 15

ER -

The induction of BDNF and c-fos mRNA in the hippocampal formation after febrile seizures

Abstract

Keywords

ASJC Scopus subject areas

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