The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents

José A. Ferreira; Lino Gonçalves; Jahed Naghipoor; Paula de Oliveira; Timon Rabczuk

doi:10.1016/j.mbs.2016.11.005

The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents

José A. Ferreira, Lino Gonçalves, Jahed Naghipoor, Paula de Oliveira, Timon Rabczuk

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.

Original language	English
Pages (from-to)	71-83
Number of pages	13
Journal	Mathematical Biosciences
Volume	283
DOIs	https://doi.org/10.1016/j.mbs.2016.11.005
Publication status	Published - 2017 Jan 1

Bibliographical note

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

Atherosclerotic plaque
Drug eluting stent
Numerical simulation
Porosity

ASJC Scopus subject areas

Statistics and Probability
Modelling and Simulation
General Biochemistry,Genetics and Molecular Biology
General Immunology and Microbiology
General Agricultural and Biological Sciences
Applied Mathematics

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10.1016/j.mbs.2016.11.005

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abstract = "In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.",

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AU - Ferreira, José A.

AU - Gonçalves, Lino

AU - Naghipoor, Jahed

AU - de Oliveira, Paula

AU - Rabczuk, Timon

PY - 2017/1/1

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KW - Numerical simulation

KW - Porosity

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ER -

The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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