The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents

José A. Ferreira; Lino Gonçalves; Jahed Naghipoor; Paula de Oliveira; Timon Rabczuk

doi:10.1016/j.mbs.2016.11.005

The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents

José A. Ferreira, Lino Gonçalves, Jahed Naghipoor, Paula de Oliveira, Timon Rabczuk

College of Engineering

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.

Original language	English
Pages (from-to)	71-83
Number of pages	13
Journal	Mathematical Biosciences
Volume	283
DOIs	https://doi.org/10.1016/j.mbs.2016.11.005
Publication status	Published - 2017 Jan 1

Keywords

Atherosclerotic plaque
Drug eluting stent
Numerical simulation
Porosity

ASJC Scopus subject areas

Statistics and Probability
Modelling and Simulation
Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)
Agricultural and Biological Sciences(all)
Applied Mathematics

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10.1016/j.mbs.2016.11.005

Cite this

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title = "The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents",

abstract = "In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.",

keywords = "Atherosclerotic plaque, Drug eluting stent, Numerical simulation, Porosity",

author = "Ferreira, {Jos{\'e} A.} and Lino Gon{\c c}alves and Jahed Naghipoor and {de Oliveira}, Paula and Timon Rabczuk",

note = "Funding Information: This work is supported by Alexander von Humboldt Foundation (AvH) under the Georg Forster Research Fellowship (HERMES), hosted at Institute of Structural Mechanics (ISM), Bauhaus-Universit{\"a}t Weimar and partially supported by the Center for Mathematics of the University of Coimbra - UID/MAT/00324/2013, funded by the Portuguese Government through FCT/MEC and co-funded by the European Regional Development Fund through the Partnership Agreement PT2020. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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doi = "10.1016/j.mbs.2016.11.005",

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AU - Ferreira, José A.

AU - Gonçalves, Lino

AU - Naghipoor, Jahed

AU - de Oliveira, Paula

AU - Rabczuk, Timon

N1 - Funding Information: This work is supported by Alexander von Humboldt Foundation (AvH) under the Georg Forster Research Fellowship (HERMES), hosted at Institute of Structural Mechanics (ISM), Bauhaus-Universität Weimar and partially supported by the Center for Mathematics of the University of Coimbra - UID/MAT/00324/2013, funded by the Portuguese Government through FCT/MEC and co-funded by the European Regional Development Fund through the Partnership Agreement PT2020. Publisher Copyright: © 2016 Elsevier Inc.

PY - 2017/1/1

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N2 - In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.

AB - In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included.

KW - Atherosclerotic plaque

KW - Drug eluting stent

KW - Numerical simulation

KW - Porosity

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JF - Mathematical Biosciences

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The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents

Abstract

Keywords

ASJC Scopus subject areas

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