TY - JOUR
T1 - The interaction between ischemia-reperfusion and immune responses in the kidney
AU - Jang, Hye Ryoun
AU - Ko, Gang Jee
AU - Wasowska, Barbara A.
AU - Rabb, Hamid
N1 - Funding Information:
Acknowledgments The authors thank Dr. Maria Teresa Gandolfo for the helpful suggestions with the manuscript. HR is supported by the US National Institutes of Health, US National Kidney Foundation, and Talecris Biotech., Inc. grants. BAW is supported by AHA, ROTRF, and Talecris Biotech., Inc. grants. HRJ is supported by the Korea Research Foundation.
PY - 2009/9
Y1 - 2009/9
N2 - Kidney ischemia-reperfusion injury (IRI) engages both the innate and adaptive immune responses. Cellular mediators of immunity, such as dendritic cells, neutrophils, macrophages, natural killer T, T, and B cells, contribute to the pathogenesis of renal injury after IRI. Postischemic kidneys express increased levels of adhesion molecules on endothelial cells and toll-like receptors on tubular epithelial cells. Soluble components of the immune system, such as complement activation proteins and cytokines, also participate in injury/repair of postischemic kidneys. Experimental studies on the immune response in kidney IRI have resulted in better understanding of the mechanisms underlying IRI and led to the discovery of novel therapeutic and diagnostic targets.
AB - Kidney ischemia-reperfusion injury (IRI) engages both the innate and adaptive immune responses. Cellular mediators of immunity, such as dendritic cells, neutrophils, macrophages, natural killer T, T, and B cells, contribute to the pathogenesis of renal injury after IRI. Postischemic kidneys express increased levels of adhesion molecules on endothelial cells and toll-like receptors on tubular epithelial cells. Soluble components of the immune system, such as complement activation proteins and cytokines, also participate in injury/repair of postischemic kidneys. Experimental studies on the immune response in kidney IRI have resulted in better understanding of the mechanisms underlying IRI and led to the discovery of novel therapeutic and diagnostic targets.
KW - Immune response
KW - Inflammation
KW - Ischemia-reperfusion injury
UR - http://www.scopus.com/inward/record.url?scp=68949205568&partnerID=8YFLogxK
U2 - 10.1007/s00109-009-0491-y
DO - 10.1007/s00109-009-0491-y
M3 - Review article
C2 - 19562316
AN - SCOPUS:68949205568
SN - 0946-2716
VL - 87
SP - 859
EP - 864
JO - Journal of Molecular Medicine
JF - Journal of Molecular Medicine
IS - 9
ER -