The LAW index as an accurate indicator of the initiation of antiviral treatment in patients with chronic hepatitis B

Jae Min Lee, Yeon Seok Seo, Tae Hyung Kim, Jem Ma Ahn, Sun Young Yim, Seung Up Kim, Young Kul Jung, Ji Hoon Kim, Hyunggin An, Hyung Joon Yim, Jong Eun Yeon, Hong Sik Lee, Kwan Soo Byun, Soon Ho Um, Chang Duck Kim, Ho Sang Ryu

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Background and Aim: Considering that inflammation and fibrosis are major factors for the indication of antiviral treatment, liver stiffness measurements could help identify patients who require antiviral treatment. This study evaluated factors that best identify patients who require antiviral treatment and to develop a new indicator for chronic hepatitis B (CHB). Methods: Patients with CHB were randomly classified into a training or validation group, and a model for predicting necroinflammatory activity ≥ A3 or fibrosis grade ≥ F2 (A3F2) was established in the training group using binary regression analysis and validated in the validation group. Predictive efficacy was compared using area under the receiver-operating characteristics curve analysis. Results: Four-hundred ninety-two patients were enrolled. In the training group, female sex, aspartate aminotransferase-to-platelet count ratio index (APRI), and liver stiffness were independent predictors of A3F2 on multivariate analysis. These variables were used to construct a novel model, called the LAW (liver stiffness, APRI, woman) index, as follows: 1.5 × liver stiffness value (kPa) + 3.9 × APRI + 3.2 if female. The LAW index was a better predictor of A3F2 than the APRI or liver stiffness measurement in both training group (0.870; 95% confidence interval, 0.822–0.910) and validation group (0.862; 95% confidence interval, 0.813–0.903). Conclusions: The LAW index was able to accurately identify patients with CHB who required antiviral treatment. A LAW index of >10.1 could be a strong indicator for the initiation of antiviral treatment in patients with CHB.

Original languageEnglish
Pages (from-to)208-214
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number1
Publication statusPublished - 2017 Jan 1

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (HI10C2020).

Publisher Copyright:
© 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd


  • APRI
  • antiviral treatment
  • chronic hepatitis B
  • index
  • liver stiffness measurement

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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