TY - JOUR
T1 - The low number of red blood cells is an important risk factor for all-cause mortality in the general population
AU - Kim, Yong Chul
AU - Koo, Ho Suk
AU - Ahn, Shin young
AU - Oh, Se Won
AU - Kim, Sejoong
AU - Na, Ki Young
AU - Chae, Dong Wan
AU - Kim, Suhnggwon
AU - Chin, Ho Jun
PY - 2012
Y1 - 2012
N2 - Patients with advanced chronic kidney disease (CKD) show decreased hemoglobin levels. We aimed to verify the changes of red blood cell (RBC) number according to glomerular filtration rate (GFR) levels and its influence on the clinical outcome. With the data from routine health checkups of 114,496 adults, we grouped the subjects according to quartile levels of RBC number in each gender. Mortality data were from the National Statistical Office. RBC number was increased with decreasing GFR and/or the presence of a component of metabolic syndrome (MS) in subjects with GFR ≥ 50 ml/min/1.73 m2. The estimated mean RBC number of subjects with GFR 89-50 ml/min/1.73 m2 was higher compared to those with GFR ≥ 100 ml/min/1.73 m2 by ANCOVA. In men, the death rate was the highest in the 1st quartile group (1Q) of RBC number (1.22%), followed by the 2nd quartile group (2Q, 0.42%), the 3rd quartile group (3Q, 0.39%), and the 4th quartile group (4Q, 0.29%) (p < 0.001). The hazard ratio (HR) of death in 2Q, 3Q and 4Q was 0.446, 0.580, and 0.440, respectively, compared to 1Q (p < 0.001). Among men in 1Q group, subjects with hemoglobin < 14.0 g/dL showed higher mortality rate than those with hemoglobin 14.0-14.9 g/dL or ≥ 15.0 g/dL (2.3%: 0.8%: 1.1%, respectively, p < 0.001). In conclusion, the RBC number was increased according to declines of GFR in the range of GFR ≥ 50 ml/min/1.73 m2 and was an important risk factor for mortality.
AB - Patients with advanced chronic kidney disease (CKD) show decreased hemoglobin levels. We aimed to verify the changes of red blood cell (RBC) number according to glomerular filtration rate (GFR) levels and its influence on the clinical outcome. With the data from routine health checkups of 114,496 adults, we grouped the subjects according to quartile levels of RBC number in each gender. Mortality data were from the National Statistical Office. RBC number was increased with decreasing GFR and/or the presence of a component of metabolic syndrome (MS) in subjects with GFR ≥ 50 ml/min/1.73 m2. The estimated mean RBC number of subjects with GFR 89-50 ml/min/1.73 m2 was higher compared to those with GFR ≥ 100 ml/min/1.73 m2 by ANCOVA. In men, the death rate was the highest in the 1st quartile group (1Q) of RBC number (1.22%), followed by the 2nd quartile group (2Q, 0.42%), the 3rd quartile group (3Q, 0.39%), and the 4th quartile group (4Q, 0.29%) (p < 0.001). The hazard ratio (HR) of death in 2Q, 3Q and 4Q was 0.446, 0.580, and 0.440, respectively, compared to 1Q (p < 0.001). Among men in 1Q group, subjects with hemoglobin < 14.0 g/dL showed higher mortality rate than those with hemoglobin 14.0-14.9 g/dL or ≥ 15.0 g/dL (2.3%: 0.8%: 1.1%, respectively, p < 0.001). In conclusion, the RBC number was increased according to declines of GFR in the range of GFR ≥ 50 ml/min/1.73 m2 and was an important risk factor for mortality.
KW - Glomerular filtration rate
KW - Hemoglobin
KW - Metabolic syndrome
KW - Mortality
KW - Red blood cell
UR - http://www.scopus.com/inward/record.url?scp=84863853457&partnerID=8YFLogxK
U2 - 10.1620/tjem.227.149
DO - 10.1620/tjem.227.149
M3 - Article
C2 - 22729150
AN - SCOPUS:84863853457
SN - 0040-8727
VL - 227
SP - 149
EP - 159
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
IS - 2
ER -