The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis

J. Oh; R. Takahashi; S. Kondo; A. Mizoguchi; E. Adachi; R. M. Sasahara; S. Nishimura; Y. Imamura; H. Kitayama; D. B. Alexander; C. Ide; T. P. Horan; T. Arakawa; H. Yoshida; S. I. Nishikawa; Y. Itoh; M. Seiki; S. Itohara; C. Takahashi; M. M. Noda

doi:10.1016/S0092-8674(01)00597-9

The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis

J. Oh, R. Takahashi, S. Kondo, A. Mizoguchi, E. Adachi, R. M. Sasahara, S. Nishimura, Y. Imamura, H. Kitayama, D. B. Alexander, C. Ide, T. P. Horan, T. Arakawa, H. Yoshida, S. I. Nishikawa, Y. Itoh, M. Seiki, S. Itohara, C. Takahashi, M. M. Noda

Research output: Contribution to journal › Article › peer-review

620 Citations (Scopus)

Abstract

Matrix metalloproteinases (MMPs) are essential for proper extracellular matrix remodeling. We previously found that a membrane-anchored glycoprotein, RECK, negatively regulates MMP-9 and inhibits tumor invasion and metastasis. Here we show that RECK regulates two other MMPs, MMP-2 and MT1-MMP, known to be involved in cancer progression, that mice lacking a functional RECK gene die around E10.5 with defects in collagen fibrils, the basal lamina, and vascular development, and that this phenotype is partially suppressed by MMP-2 null mutation. Also, vascular sprouting is dramatically suppressed in tumors derived from RECK-expressing fibrosarcoma cells grown in nude mice. These results support a role for RECK in the regulation of MMP-2 in vivo and implicate RECK downregulation in tumor angiogenesis.

Original language	English
Pages (from-to)	789-800
Number of pages	12
Journal	Cell
Volume	107
Issue number	6
DOIs	https://doi.org/10.1016/S0092-8674(01)00597-9
Publication status	Published - 2001 Dec 14

Bibliographical note

Funding Information:
We thank M. Hooper for the E14 ES cells, Thomas N. Sato for the protocol for whole-mount immunostaining, Masatoshi Maki for technical advice, Ryoichi Nemori (FUJIFILM) for the FIZ materials, Emi Nishimoto and Takashi Kawai for technical assistance, and Aki Miyazaki for secretarial assistance. We are also grateful to Drs. Yoji Ikawa and Haruo Sugano for generous support and encouragement and to Drs. Robert A. Weinberg and Rudolf Jaenisch for discussion. This work was supported by grants from the Ministry of Education, Science, Sports, and Culture of Japan to C.T. and M.N. and from Amgen, Sankyo, Co. Ltd., and Takeda Science Foundation to M.N.

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0092-8674(01)00597-9

Cite this

Oh, J., Takahashi, R., Kondo, S., Mizoguchi, A., Adachi, E., Sasahara, R. M., Nishimura, S., Imamura, Y., Kitayama, H., Alexander, D. B., Ide, C., Horan, T. P., Arakawa, T., Yoshida, H., Nishikawa, S. I., Itoh, Y., Seiki, M., Itohara, S., Takahashi, C., & Noda, M. M. (2001). The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis. Cell, 107(6), 789-800. https://doi.org/10.1016/S0092-8674(01)00597-9

Oh, J, Takahashi, R, Kondo, S, Mizoguchi, A, Adachi, E, Sasahara, RM, Nishimura, S, Imamura, Y, Kitayama, H, Alexander, DB, Ide, C, Horan, TP, Arakawa, T, Yoshida, H, Nishikawa, SI, Itoh, Y, Seiki, M, Itohara, S, Takahashi, C & Noda, MM 2001, 'The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis', Cell, vol. 107, no. 6, pp. 789-800. https://doi.org/10.1016/S0092-8674(01)00597-9

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title = "The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis",

abstract = "Matrix metalloproteinases (MMPs) are essential for proper extracellular matrix remodeling. We previously found that a membrane-anchored glycoprotein, RECK, negatively regulates MMP-9 and inhibits tumor invasion and metastasis. Here we show that RECK regulates two other MMPs, MMP-2 and MT1-MMP, known to be involved in cancer progression, that mice lacking a functional RECK gene die around E10.5 with defects in collagen fibrils, the basal lamina, and vascular development, and that this phenotype is partially suppressed by MMP-2 null mutation. Also, vascular sprouting is dramatically suppressed in tumors derived from RECK-expressing fibrosarcoma cells grown in nude mice. These results support a role for RECK in the regulation of MMP-2 in vivo and implicate RECK downregulation in tumor angiogenesis.",

author = "J. Oh and R. Takahashi and S. Kondo and A. Mizoguchi and E. Adachi and Sasahara, {R. M.} and S. Nishimura and Y. Imamura and H. Kitayama and Alexander, {D. B.} and C. Ide and Horan, {T. P.} and T. Arakawa and H. Yoshida and Nishikawa, {S. I.} and Y. Itoh and M. Seiki and S. Itohara and C. Takahashi and Noda, {M. M.}",

note = "Funding Information: We thank M. Hooper for the E14 ES cells, Thomas N. Sato for the protocol for whole-mount immunostaining, Masatoshi Maki for technical advice, Ryoichi Nemori (FUJIFILM) for the FIZ materials, Emi Nishimoto and Takashi Kawai for technical assistance, and Aki Miyazaki for secretarial assistance. We are also grateful to Drs. Yoji Ikawa and Haruo Sugano for generous support and encouragement and to Drs. Robert A. Weinberg and Rudolf Jaenisch for discussion. This work was supported by grants from the Ministry of Education, Science, Sports, and Culture of Japan to C.T. and M.N. and from Amgen, Sankyo, Co. Ltd., and Takeda Science Foundation to M.N.",

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T1 - The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis

AU - Oh, J.

AU - Takahashi, R.

AU - Kondo, S.

AU - Mizoguchi, A.

AU - Adachi, E.

AU - Sasahara, R. M.

AU - Nishimura, S.

AU - Imamura, Y.

AU - Kitayama, H.

AU - Alexander, D. B.

AU - Ide, C.

AU - Horan, T. P.

AU - Arakawa, T.

AU - Yoshida, H.

AU - Nishikawa, S. I.

AU - Itoh, Y.

AU - Seiki, M.

AU - Itohara, S.

AU - Takahashi, C.

AU - Noda, M. M.

N1 - Funding Information: We thank M. Hooper for the E14 ES cells, Thomas N. Sato for the protocol for whole-mount immunostaining, Masatoshi Maki for technical advice, Ryoichi Nemori (FUJIFILM) for the FIZ materials, Emi Nishimoto and Takashi Kawai for technical assistance, and Aki Miyazaki for secretarial assistance. We are also grateful to Drs. Yoji Ikawa and Haruo Sugano for generous support and encouragement and to Drs. Robert A. Weinberg and Rudolf Jaenisch for discussion. This work was supported by grants from the Ministry of Education, Science, Sports, and Culture of Japan to C.T. and M.N. and from Amgen, Sankyo, Co. Ltd., and Takeda Science Foundation to M.N.

PY - 2001/12/14

Y1 - 2001/12/14

N2 - Matrix metalloproteinases (MMPs) are essential for proper extracellular matrix remodeling. We previously found that a membrane-anchored glycoprotein, RECK, negatively regulates MMP-9 and inhibits tumor invasion and metastasis. Here we show that RECK regulates two other MMPs, MMP-2 and MT1-MMP, known to be involved in cancer progression, that mice lacking a functional RECK gene die around E10.5 with defects in collagen fibrils, the basal lamina, and vascular development, and that this phenotype is partially suppressed by MMP-2 null mutation. Also, vascular sprouting is dramatically suppressed in tumors derived from RECK-expressing fibrosarcoma cells grown in nude mice. These results support a role for RECK in the regulation of MMP-2 in vivo and implicate RECK downregulation in tumor angiogenesis.

AB - Matrix metalloproteinases (MMPs) are essential for proper extracellular matrix remodeling. We previously found that a membrane-anchored glycoprotein, RECK, negatively regulates MMP-9 and inhibits tumor invasion and metastasis. Here we show that RECK regulates two other MMPs, MMP-2 and MT1-MMP, known to be involved in cancer progression, that mice lacking a functional RECK gene die around E10.5 with defects in collagen fibrils, the basal lamina, and vascular development, and that this phenotype is partially suppressed by MMP-2 null mutation. Also, vascular sprouting is dramatically suppressed in tumors derived from RECK-expressing fibrosarcoma cells grown in nude mice. These results support a role for RECK in the regulation of MMP-2 in vivo and implicate RECK downregulation in tumor angiogenesis.

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AN - SCOPUS:18244367390

SN - 0092-8674

VL - 107

SP - 789

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JO - Cell

JF - Cell

IS - 6

ER -

The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesis

Abstract

Bibliographical note

ASJC Scopus subject areas

UN SDGs

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