The molecular characteristics of circumsporozoite protein gene subtypes from Plasmodium vivax isolates in Republic of Korea

Tak Kim; Yoo Jin Kim; Ki Joon Song; Jin Won Song; Sang Hoon Cha; Yong Ku Kim; Young Kyu Shin; In Bum Suh; Chae Seung Lim

doi:10.1007/s00436-002-0699-z

The molecular characteristics of circumsporozoite protein gene subtypes from Plasmodium vivax isolates in Republic of Korea

Tak Kim, Yoo Jin Kim, Ki Joon Song, Jin Won Song, Sang Hoon Cha, Yong Ku Kim, Young Kyu Shin, In Bum Suh, Chae Seung Lim

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The circumsporozoite protein (CSP) of Plasmodium vivax has two sequence types, VK210 and VK247, each of which has a characteristic tandem amino acid repetition. Previous studies report that a resurgent Korean strain has unique amino acid sequences in tandem repeats and post-repeat areas compared to other strains of P. vivax. We have found another molecular subtype of the CSP gene from resurgent Korea isolates. New strains show a total of eighteen amino acid repeats and different amino acid repeat patterns compared with previous resurgent Korean isolates. In the post-repeat region, AGGNAANKKAEDAGGNA and three repeats of the sequence GGNA was found in all six isolates. These results of sequence comparison revealed that there are two types of isolates based on CSP in South Korea.

Original language	English
Pages (from-to)	1051-1054
Number of pages	4
Journal	Parasitology Research
Volume	88
Issue number	12
DOIs	https://doi.org/10.1007/s00436-002-0699-z
Publication status	Published - 2002

ASJC Scopus subject areas

Parasitology
General Veterinary
Insect Science
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00436-002-0699-z

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title = "The molecular characteristics of circumsporozoite protein gene subtypes from Plasmodium vivax isolates in Republic of Korea",

abstract = "The circumsporozoite protein (CSP) of Plasmodium vivax has two sequence types, VK210 and VK247, each of which has a characteristic tandem amino acid repetition. Previous studies report that a resurgent Korean strain has unique amino acid sequences in tandem repeats and post-repeat areas compared to other strains of P. vivax. We have found another molecular subtype of the CSP gene from resurgent Korea isolates. New strains show a total of eighteen amino acid repeats and different amino acid repeat patterns compared with previous resurgent Korean isolates. In the post-repeat region, AGGNAANKKAEDAGGNA and three repeats of the sequence GGNA was found in all six isolates. These results of sequence comparison revealed that there are two types of isolates based on CSP in South Korea.",

author = "Tak Kim and Kim, {Yoo Jin} and Song, {Ki Joon} and Song, {Jin Won} and Cha, {Sang Hoon} and Kim, {Yong Ku} and Shin, {Young Kyu} and Suh, {In Bum} and Lim, {Chae Seung}",

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T1 - The molecular characteristics of circumsporozoite protein gene subtypes from Plasmodium vivax isolates in Republic of Korea

AU - Kim, Tak

AU - Kim, Yoo Jin

AU - Song, Ki Joon

AU - Song, Jin Won

AU - Cha, Sang Hoon

AU - Kim, Yong Ku

AU - Shin, Young Kyu

AU - Suh, In Bum

AU - Lim, Chae Seung

PY - 2002

Y1 - 2002

N2 - The circumsporozoite protein (CSP) of Plasmodium vivax has two sequence types, VK210 and VK247, each of which has a characteristic tandem amino acid repetition. Previous studies report that a resurgent Korean strain has unique amino acid sequences in tandem repeats and post-repeat areas compared to other strains of P. vivax. We have found another molecular subtype of the CSP gene from resurgent Korea isolates. New strains show a total of eighteen amino acid repeats and different amino acid repeat patterns compared with previous resurgent Korean isolates. In the post-repeat region, AGGNAANKKAEDAGGNA and three repeats of the sequence GGNA was found in all six isolates. These results of sequence comparison revealed that there are two types of isolates based on CSP in South Korea.

AB - The circumsporozoite protein (CSP) of Plasmodium vivax has two sequence types, VK210 and VK247, each of which has a characteristic tandem amino acid repetition. Previous studies report that a resurgent Korean strain has unique amino acid sequences in tandem repeats and post-repeat areas compared to other strains of P. vivax. We have found another molecular subtype of the CSP gene from resurgent Korea isolates. New strains show a total of eighteen amino acid repeats and different amino acid repeat patterns compared with previous resurgent Korean isolates. In the post-repeat region, AGGNAANKKAEDAGGNA and three repeats of the sequence GGNA was found in all six isolates. These results of sequence comparison revealed that there are two types of isolates based on CSP in South Korea.

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U2 - 10.1007/s00436-002-0699-z

DO - 10.1007/s00436-002-0699-z

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The molecular characteristics of circumsporozoite protein gene subtypes from Plasmodium vivax isolates in Republic of Korea

Abstract

ASJC Scopus subject areas

UN SDGs

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