The monitoring of relative changes in compartmental compliances of brain

Dong Joo Kim; Magdalena Kasprowicz; Emmanuel Carrera; Gianluca Castellani; Christian Zweifel; Andrea Lavinio; Peter Smielewski; Michael P.F. Sutcliffe; John D. Pickard; Marek Czosnyka

doi:10.1088/0967-3334/30/7/009

The monitoring of relative changes in compartmental compliances of brain

Dong Joo Kim, Magdalena Kasprowicz, Emmanuel Carrera, Gianluca Castellani, Christian Zweifel, Andrea Lavinio, Peter Smielewski, Michael P.F. Sutcliffe, John D. Pickard, Marek Czosnyka

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

The study aimed to develop a computational method for assessing relative changes in compartmental compliances within the brain: the arterial bed and the cerebrospinal space. The method utilizes the relationship between pulsatile components in the arterial blood volume, arterial blood pressure (ABP) and intracranial pressure (ICP). It was verified by using clinical recordings of intracranial pressure plateau waves, when massive vasodilatation accompanying plateau waves produces changes in brain compliances of the arterial bed (C _a) and compliance of the cerebrospinal space (C_i). Ten patients admitted after head injury with a median Glasgow Coma Score of 6 were studied retrospectively. ABP was directly monitored from the radial artery. Changes in the cerebral arterial blood volume were assessed using Transcranial Doppler (TCD) ultrasonography by digital integration of inflow blood velocity. During plateau waves, ICP increased (P = 0.001), CPP decreased (P = 0.001), ABP remained constant (P = 0.532), blood flow velocity decreased (P = 0.001). Calculated compliance of the arterial bed C_a increased significantly (P = 0.001); compliance of the CSF space C_i decreased (P = 0.001). We concluded that the method allows for continuous monitoring of relative changes in brain compartmental compliances. Plateau waves affect the balance between vascular and CSF compartments, which is reflected by the inverse change of compliance of the cerebral arterial bed and global compliance of the CSF space.

Original language	English
Pages (from-to)	647-659
Number of pages	13
Journal	Physiological Measurement
Volume	30
Issue number	7
DOIs	https://doi.org/10.1088/0967-3334/30/7/009
Publication status	Published - 2009
Externally published	Yes

Keywords

Arterial bed compliance
Brain
Brain compartmental compliance
CSF space compliance
Cerebral blood flow
Intracranial pressure
TCD monitoring

ASJC Scopus subject areas

Biophysics
Physiology
Biomedical Engineering
Physiology (medical)

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10.1088/0967-3334/30/7/009

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title = "The monitoring of relative changes in compartmental compliances of brain",

abstract = "The study aimed to develop a computational method for assessing relative changes in compartmental compliances within the brain: the arterial bed and the cerebrospinal space. The method utilizes the relationship between pulsatile components in the arterial blood volume, arterial blood pressure (ABP) and intracranial pressure (ICP). It was verified by using clinical recordings of intracranial pressure plateau waves, when massive vasodilatation accompanying plateau waves produces changes in brain compliances of the arterial bed (C a) and compliance of the cerebrospinal space (Ci). Ten patients admitted after head injury with a median Glasgow Coma Score of 6 were studied retrospectively. ABP was directly monitored from the radial artery. Changes in the cerebral arterial blood volume were assessed using Transcranial Doppler (TCD) ultrasonography by digital integration of inflow blood velocity. During plateau waves, ICP increased (P = 0.001), CPP decreased (P = 0.001), ABP remained constant (P = 0.532), blood flow velocity decreased (P = 0.001). Calculated compliance of the arterial bed Ca increased significantly (P = 0.001); compliance of the CSF space Ci decreased (P = 0.001). We concluded that the method allows for continuous monitoring of relative changes in brain compartmental compliances. Plateau waves affect the balance between vascular and CSF compartments, which is reflected by the inverse change of compliance of the cerebral arterial bed and global compliance of the CSF space.",

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AU - Kim, Dong Joo

AU - Kasprowicz, Magdalena

AU - Carrera, Emmanuel

AU - Castellani, Gianluca

AU - Zweifel, Christian

AU - Lavinio, Andrea

AU - Smielewski, Peter

AU - Sutcliffe, Michael P.F.

AU - Pickard, John D.

AU - Czosnyka, Marek

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The monitoring of relative changes in compartmental compliances of brain

Abstract

Keywords

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