The multi-faceted role of the actin cap in cellular mechanosensation and mechanotransduction

Dong Hwee Kim, Allison B. Chambliss, Denis Wirtz

Research output: Contribution to journalReview articlepeer-review

63 Citations (Scopus)


The perinuclear actin cap (or actin cap) is a recently characterized cytoskeletal organelle composed of thick, parallel, and highly contractile acto-myosin filaments that are specifically anchored to the apical surface of the interphase nucleus. The actin cap is present in a wide range of adherent eukaryotic cells, but is disrupted in several human diseases, including laminopathies and cancer. Through its large terminating focal adhesions and anchorage to the nuclear lamina and nuclear envelope through LINC complexes, the perinuclear actin cap plays a critical role both in mechanosensation and mechanotransduction, the ability of cells to sense changes in matrix compliance and to respond to mechanical forces, respectively.

Original languageEnglish
Pages (from-to)5516-5523
Number of pages8
JournalSoft Matter
Issue number23
Publication statusPublished - 2013 Jun 21
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry
  • Condensed Matter Physics


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