The polymorphisms k469e and g261r of intercellular adhesion molecule-1 and susceptibility to inflammatory bowel disease: A meta-Analysis

Objective: The aim of this study was to explore whether polymorphisms of intercellular adhesion molecule-1 (ICAM-1) are associated with susceptibility to Crohn's disease (CD) and ulcerative colitis (UC). Methods: The authors conducted a meta-Analysis on the associations between the polymorphisms K469E and G241R of ICAM-1 and susceptibility to CD and UC. Results: A total of 8 studies with 801 patients with CD, 672 patients with UC, and 1,828 controls were included in the meta-Analysis. The meta-Analysis revealed no association between CD and the ICAM-1 469E allele among the subjects (OR=1.175, 95% CI=0.901-1.533, p=0.233). However, stratification by ethnicity indicated an association between the ICAM-1 469E allele and CD in Europeans (OR=1.425, 95% CI=1.013-2.002, p=0.042). Meta-Analysis using the homozygosity also showed an association with CD in Europeans (OR=2.054, 95% CI=1.036-4.073, p=0.039). The meta-Analysis revealed no association between UC and the ICAM-1 K469E polymorphism. No association between CD or UC and the ICAM-1 G241R polymorphism was observed. Conclusions: This meta-Analysis demonstrates that the ICAM-1 K469E polymorphism may be associated with susceptibility to CD in Europeans, but no association was found between ICAM-1 K469E and UC. In contrast, the G241R polymorphism was not found to be associated with susceptibility to either CD or UC.