The potential for skin irritation, phototoxicity, and sensitization of ZnO nanoparticles

Yeon Sue Jang; Eun Young Lee; Yoon Hee Park; Sang Hoon Jeong; Sang Geun Lee; Yu Ri Kim; Meyoung Kon Kim; Sang Wook Son

doi:10.1007/s13273-012-0021-9

The potential for skin irritation, phototoxicity, and sensitization of ZnO nanoparticles

Yeon Sue Jang, Eun Young Lee, Yoon Hee Park, Sang Hoon Jeong, Sang Geun Lee, Yu Ri Kim, Meyoung Kon Kim, Sang Wook Son

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

In spite of widely use of zinc oxide (ZnO) nanoparticles (NPs) in cosmetic industry and in our daily lives, insufficient studies have evaluated the potential of their toxic response. This study was conducted to investigate the potential of cytotoxicity induced by ZnO NPs, especially influences of the surface charge and different particle size. Assessment of potential of skin irritation was estimated using human skin equivalent model (HSEM), and an animal model. And the evaluation of skin phototoxicity was tested by the 3T3 neutral red uptake test. Lastly, the potential of skin sensitization was evaluated by a local lymph node assay (LLNA). The results from this study demonstrated that ZnO NPs are not dermal sensitizers and do not induce skin irritation. But they may produce phototoxicity.

Original language	English
Pages (from-to)	171-177
Number of pages	7
Journal	Molecular and Cellular Toxicology
Volume	8
Issue number	2
DOIs	https://doi.org/10.1007/s13273-012-0021-9
Publication status	Published - 2012 Jun

Keywords

Cytotoxicity
Phototoxicity
Skin irritation
Skin sensitization
ZnO

ASJC Scopus subject areas

Pathology and Forensic Medicine
Toxicology
General Pharmacology, Toxicology and Pharmaceutics
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s13273-012-0021-9

Cite this

@article{93d1924c1e70474ebc841fe244141f2b,

title = "The potential for skin irritation, phototoxicity, and sensitization of ZnO nanoparticles",

abstract = "In spite of widely use of zinc oxide (ZnO) nanoparticles (NPs) in cosmetic industry and in our daily lives, insufficient studies have evaluated the potential of their toxic response. This study was conducted to investigate the potential of cytotoxicity induced by ZnO NPs, especially influences of the surface charge and different particle size. Assessment of potential of skin irritation was estimated using human skin equivalent model (HSEM), and an animal model. And the evaluation of skin phototoxicity was tested by the 3T3 neutral red uptake test. Lastly, the potential of skin sensitization was evaluated by a local lymph node assay (LLNA). The results from this study demonstrated that ZnO NPs are not dermal sensitizers and do not induce skin irritation. But they may produce phototoxicity.",

keywords = "Cytotoxicity, Phototoxicity, Skin irritation, Skin sensitization, ZnO",

author = "Jang, {Yeon Sue} and Lee, {Eun Young} and Park, {Yoon Hee} and Jeong, {Sang Hoon} and Lee, {Sang Geun} and Kim, {Yu Ri} and Kim, {Meyoung Kon} and Son, {Sang Wook}",

year = "2012",

month = jun,

doi = "10.1007/s13273-012-0021-9",

language = "English",

volume = "8",

pages = "171--177",

journal = "Molecular and Cellular Toxicology",

issn = "1738-642X",

publisher = "Springer Verlag",

number = "2",

}

TY - JOUR

T1 - The potential for skin irritation, phototoxicity, and sensitization of ZnO nanoparticles

AU - Jang, Yeon Sue

AU - Lee, Eun Young

AU - Park, Yoon Hee

AU - Jeong, Sang Hoon

AU - Lee, Sang Geun

AU - Kim, Yu Ri

AU - Kim, Meyoung Kon

AU - Son, Sang Wook

PY - 2012/6

Y1 - 2012/6

N2 - In spite of widely use of zinc oxide (ZnO) nanoparticles (NPs) in cosmetic industry and in our daily lives, insufficient studies have evaluated the potential of their toxic response. This study was conducted to investigate the potential of cytotoxicity induced by ZnO NPs, especially influences of the surface charge and different particle size. Assessment of potential of skin irritation was estimated using human skin equivalent model (HSEM), and an animal model. And the evaluation of skin phototoxicity was tested by the 3T3 neutral red uptake test. Lastly, the potential of skin sensitization was evaluated by a local lymph node assay (LLNA). The results from this study demonstrated that ZnO NPs are not dermal sensitizers and do not induce skin irritation. But they may produce phototoxicity.

AB - In spite of widely use of zinc oxide (ZnO) nanoparticles (NPs) in cosmetic industry and in our daily lives, insufficient studies have evaluated the potential of their toxic response. This study was conducted to investigate the potential of cytotoxicity induced by ZnO NPs, especially influences of the surface charge and different particle size. Assessment of potential of skin irritation was estimated using human skin equivalent model (HSEM), and an animal model. And the evaluation of skin phototoxicity was tested by the 3T3 neutral red uptake test. Lastly, the potential of skin sensitization was evaluated by a local lymph node assay (LLNA). The results from this study demonstrated that ZnO NPs are not dermal sensitizers and do not induce skin irritation. But they may produce phototoxicity.

KW - Cytotoxicity

KW - Phototoxicity

KW - Skin irritation

KW - Skin sensitization

KW - ZnO

UR - http://www.scopus.com/inward/record.url?scp=84866103964&partnerID=8YFLogxK

U2 - 10.1007/s13273-012-0021-9

DO - 10.1007/s13273-012-0021-9

M3 - Article

AN - SCOPUS:84866103964

SN - 1738-642X

VL - 8

SP - 171

EP - 177

JO - Molecular and Cellular Toxicology

JF - Molecular and Cellular Toxicology

IS - 2

ER -

The potential for skin irritation, phototoxicity, and sensitization of ZnO nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this