The ratio of estrogen receptor α to estrogen receptor β in adipose tissue is associated with leptin production and obesity

Jung Ho Shin, Jun Young Hur, Hong Seog Seo, Yu A. Jeong, Jae Kwan Lee, Min Jeong Oh, Tak Kim, Ho Suk Saw, Sun Haeng Kim

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


The loss of estrogen associated with menopause is suspected to play an important regulatory role in changes of fat metabolism and obesity. To evaluate the relationship between obesity and the ratio of estrogen receptor subtypes (ERα/ERβ) in adipose tissues in pre- and postmenopausal women, we measured the anthropometric indices of 31 premenopausal women and 12 postmenopausal women. Serum samples, subcutaneous and omental adipose tissues were also obtained from study participants. Serum leptin, adiponectin, IL-6, and TNF-α levels were measured using ELISA methods. Real-time RT-PCR analysis was performed to detect and to compare mRNA levels of leptin and estrogen receptor subtypes (ERα and ERβ) from adipose tissues. The ratio of abdominal subcutaneous to omental adipose tissue for the ER subtypes (Sc-Om ratio of the ER subtypes), i.e., subcutaneous ERα/ERβ over omental ERα/ERβ, showed significant correlations with anthropometric indices including BMI (r = 0.801, p < 0.05) and waist circumference (r = 0.696, p < 0.05) in both pre- and postmenopausal women. The Sc-Om ratio of the ER subtypes also had a significant correlation with the serum leptin level (r = 0.735, p < 0.05) as well as the mRNA level of leptin in omental adipose tissue (r = 0.753, p < 0.05). However, there were no significant differences between the pre- and postmenopausal groups with regard to the expressed level of ER subtypes. In conclusion, our study results showed that the ratio of ERα to ERβ in adipose tissue was associated with obesity as well as the serum level and production of leptin in omental adipose tissue.

Original languageEnglish
Pages (from-to)592-599
Number of pages8
Issue number6-7
Publication statusPublished - 2007 Jun
Externally publishedYes


  • Adipose tissue
  • Anthropometric index
  • Estrogen receptor
  • Leptin
  • Menopause

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Endocrinology
  • Pharmacology
  • Clinical Biochemistry
  • Organic Chemistry


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