The relationship between twin births and maternal risk of breast cancer: A meta-analysis

Hye Sook Kim; Ok Hee Woo; Kyong Hwa Park; Sang Uk Woo; Dae Sik Yang; Ae Ree Kim; Eun Sook Lee; Jae Bok Lee; Yeul Hong Kim; Jun Suk Kim; Jae Hong Seo

doi:10.1007/s10549-011-1779-5

The relationship between twin births and maternal risk of breast cancer: A meta-analysis

Hye Sook Kim, Ok Hee Woo, Kyong Hwa Park, Sang Uk Woo, Dae Sik Yang, Ae Ree Kim, Eun Sook Lee, Jae Bok Lee, Yeul Hong Kim, Jun Suk Kim, Jae Hong Seo

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Women who undergo a greater number of menstrual cycles may be at increased risk of breast cancer, possibly due to cumulative exposure to ovarian hormones. Pregnancy reduces the lifetime number of menstrual cycles and also influences the levels of ovarian hormones. Twin pregnancies differ from singleton pregnancies in both hormone levels and perinatal changes. To date, a meta-analysis on the effects of twin birth on the risk of maternal breast cancer has not been conducted. Among 17 relevant publications identified in a systematic search, some suggest that twin births may be associated with lower breast cancer risk but others do not; therefore, the results are inconclusive. Although our pooled results of all 17 published studies did not show a reduced maternal risk of breast cancer for twin births (HR 0.94; 95% CI = 0.87-1.02; P = 0.127), a trend toward reduced maternal risk of breast cancer was identified in a subgroup analysis of cohort studies (HR 0.91; 95% CI = 0.83-1.01; P = 0.068). The results of this meta-analysis suggest that twin pregnancy does not significantly decrease the maternal risk of breast cancer.

Original language	English
Pages (from-to)	671-677
Number of pages	7
Journal	Breast Cancer Research and Treatment
Volume	131
Issue number	2
DOIs	https://doi.org/10.1007/s10549-011-1779-5
Publication status	Published - 2012 Jan

Bibliographical note

Funding Information:
Acknowledgments This study was supported by a grant of the Korean Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A040151).

Keywords

Breast cancer
Meta-analysis
Twin births

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10549-011-1779-5

Cite this

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title = "The relationship between twin births and maternal risk of breast cancer: A meta-analysis",

abstract = "Women who undergo a greater number of menstrual cycles may be at increased risk of breast cancer, possibly due to cumulative exposure to ovarian hormones. Pregnancy reduces the lifetime number of menstrual cycles and also influences the levels of ovarian hormones. Twin pregnancies differ from singleton pregnancies in both hormone levels and perinatal changes. To date, a meta-analysis on the effects of twin birth on the risk of maternal breast cancer has not been conducted. Among 17 relevant publications identified in a systematic search, some suggest that twin births may be associated with lower breast cancer risk but others do not; therefore, the results are inconclusive. Although our pooled results of all 17 published studies did not show a reduced maternal risk of breast cancer for twin births (HR 0.94; 95% CI = 0.87-1.02; P = 0.127), a trend toward reduced maternal risk of breast cancer was identified in a subgroup analysis of cohort studies (HR 0.91; 95% CI = 0.83-1.01; P = 0.068). The results of this meta-analysis suggest that twin pregnancy does not significantly decrease the maternal risk of breast cancer.",

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doi = "10.1007/s10549-011-1779-5",

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AU - Lee, Eun Sook

AU - Lee, Jae Bok

AU - Kim, Yeul Hong

AU - Kim, Jun Suk

AU - Seo, Jae Hong

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The relationship between twin births and maternal risk of breast cancer: A meta-analysis

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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