The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis

Sundo Jung; Yoon Kyung Park; Jung Hoon Shin; Hyunji Lee; Soo Young Kim; Gap Ryol Lee; Se Ho Park

doi:10.3858/emm.2010.42.8.055

The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis

Sundo Jung
, Yoon Kyung Park
, Jung Hoon Shin
, Hyunji Lee
, Soo Young Kim
, Gap Ryol Lee
, Se Ho Park^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

TGF-β-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved in the pathogenesis of Th1-mediated autoimmune joint inflammation and Th2-mediated allergic pulmonary inflammation. In this study, we investigated the effect of CD1d-restricted NKT cells in the Tol-APCs-mediated suppression of autoimmune disease using a murine CIA model. When CIA-induced mice were treated with Tol-APCs obtained from CD1d^+/- or CD1d^-/- mice, unlike CD1d^+/- APCs, CD1d^-/- Tol-APCs failed to suppress CIA. More specifically, CD1d^-/- Tol-APCs failed to suppress the production of inflammatory cytokines and the induction of Th2 responses by antigen-specific CD4 T cells both in vitro and in vivo. Our results demonstrate that the presence of CD1d-restricted NKT cells is critical for the induction of Tol-APCs-mediated suppression of CIA.

Original language	English
Pages (from-to)	547-554
Number of pages	8
Journal	Experimental and Molecular Medicine
Volume	42
Issue number	8
DOIs	https://doi.org/10.3858/emm.2010.42.8.055
Publication status	Published - 2010

Keywords

Antigen-presenting cells
Antigens
Arthritis
CD1d
Experimental
Immune tolerance
Natural killer T-cells

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry

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10.3858/emm.2010.42.8.055

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title = "The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis",

abstract = "TGF-β-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved in the pathogenesis of Th1-mediated autoimmune joint inflammation and Th2-mediated allergic pulmonary inflammation. In this study, we investigated the effect of CD1d-restricted NKT cells in the Tol-APCs-mediated suppression of autoimmune disease using a murine CIA model. When CIA-induced mice were treated with Tol-APCs obtained from CD1d+/- or CD1d-/- mice, unlike CD1d+/- APCs, CD1d-/- Tol-APCs failed to suppress CIA. More specifically, CD1d-/- Tol-APCs failed to suppress the production of inflammatory cytokines and the induction of Th2 responses by antigen-specific CD4 T cells both in vitro and in vivo. Our results demonstrate that the presence of CD1d-restricted NKT cells is critical for the induction of Tol-APCs-mediated suppression of CIA.",

keywords = "Antigen-presenting cells, Antigens, Arthritis, CD1d, Experimental, Immune tolerance, Natural killer T-cells",

author = "Sundo Jung and Park, \{Yoon Kyung\} and Shin, \{Jung Hoon\} and Hyunji Lee and Kim, \{Soo Young\} and Lee, \{Gap Ryol\} and Park, \{Se Ho\}",

year = "2010",

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AU - Jung, Sundo

AU - Park, Yoon Kyung

AU - Shin, Jung Hoon

AU - Lee, Hyunji

AU - Kim, Soo Young

AU - Lee, Gap Ryol

AU - Park, Se Ho

PY - 2010

Y1 - 2010

N2 - TGF-β-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved in the pathogenesis of Th1-mediated autoimmune joint inflammation and Th2-mediated allergic pulmonary inflammation. In this study, we investigated the effect of CD1d-restricted NKT cells in the Tol-APCs-mediated suppression of autoimmune disease using a murine CIA model. When CIA-induced mice were treated with Tol-APCs obtained from CD1d+/- or CD1d-/- mice, unlike CD1d+/- APCs, CD1d-/- Tol-APCs failed to suppress CIA. More specifically, CD1d-/- Tol-APCs failed to suppress the production of inflammatory cytokines and the induction of Th2 responses by antigen-specific CD4 T cells both in vitro and in vivo. Our results demonstrate that the presence of CD1d-restricted NKT cells is critical for the induction of Tol-APCs-mediated suppression of CIA.

AB - TGF-β-induced tolerogenic-antigen presenting cells (Tol-APCs) could induce suppression of autoimmune diseases such as collagen-induced arthritis (CIA) and allergic asthma. In contrast, many studies have shown that NKT cells are involved in the pathogenesis of Th1-mediated autoimmune joint inflammation and Th2-mediated allergic pulmonary inflammation. In this study, we investigated the effect of CD1d-restricted NKT cells in the Tol-APCs-mediated suppression of autoimmune disease using a murine CIA model. When CIA-induced mice were treated with Tol-APCs obtained from CD1d+/- or CD1d-/- mice, unlike CD1d+/- APCs, CD1d-/- Tol-APCs failed to suppress CIA. More specifically, CD1d-/- Tol-APCs failed to suppress the production of inflammatory cytokines and the induction of Th2 responses by antigen-specific CD4 T cells both in vitro and in vivo. Our results demonstrate that the presence of CD1d-restricted NKT cells is critical for the induction of Tol-APCs-mediated suppression of CIA.

KW - Antigen-presenting cells

KW - Antigens

KW - Arthritis

KW - CD1d

KW - Experimental

KW - Immune tolerance

KW - Natural killer T-cells

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ER -

The requirement of natural killer T-cells in tolerogenic APCs-mediated suppression of collagen-induced arthritis

Abstract

Keywords

ASJC Scopus subject areas

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