The role of oxytocin, vasopressin, and their receptors at nociceptors in peripheral pain modulation

Haiyan Zheng, Ji Yeon Lim, Yerin Kim, Sang Taek Jung, Sun Wook Hwang

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)


Oxytocin and vasopressin are neurohypophyseal hormones with sequence similarity and play a central role in bodily homeostatic regulation. Pain is currently understood to be an important phenotype that those two neurohormones strongly downregulate. Nociceptors, the first component of the ascending neural circuit for pain signals, have constantly been shown to be modulated by those peptides. The nociceptor modulation appears to be critical in pain attenuation, which has led to a gradual increase in scientific interest about their physiological processes and also drawn attention to their translational potentials. This review focused on what are recently understood and stay under investigation in the functional modulation of nociceptors by oxytocin and vasopressin. Effort to produce a nociceptor-specific view could help to construct a more systematic picture of the peripheral pain modulation by oxytocin and vasopressin.

Original languageEnglish
Article number100942
JournalFrontiers in Neuroendocrinology
Publication statusPublished - 2021 Oct

Bibliographical note

Funding Information:
This work was supported by grants from the National Research Foundation of Korea (2017R1A2B2001817, 2017M3C7A1025600, and 2019R1A4A1029000).

Publisher Copyright:
© 2021 Elsevier Inc.


  • Analgesia
  • Nociceptor
  • Oxytocin
  • Pain
  • Receptor
  • Vasopressin

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems


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