The role of senescence of bone marrow cells in acute kidney injury

Junyong Lee, Yoon Sook Ko, Hee Young Lee, Jihyun Yang, Sewon Oh, Sang Kyung Jo, Wonyong Cho, Myung Gyu Kim

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)


    Background: The prevalence of acute kidney injury (AKI) in elderly patients has grown considerably. Age-associated changes in the immune system can be one of the critical factors determining AKI outcomes. This study aimed to investigate the role of senescence of bone marrow (BM)-derived cells in the development of AKI, focusing on the immune response. Methods: Female 7-week-old C57BL/6 mice were irradiated and treated with BM cells from either 48-week-old or 8-week-old male mice. Ischemia-reperfusion injury (IRI) was induced, and their functional deterioration, histological tubular damage, and inflammatory responses were compared. For the in vitro study, lipopolysaccharide (LPS)-stimulated cytokine production by BM cells from old and young mice were examined. Results: At 24 hours after IRI, there was no significant difference in the number of circulating immune cells between the mice transplanted with old or young BM cells. However, the mice with old BM cells showed less functional deterioration and histological tubular injury than those with young BM cells. Moreover, macrophage infiltration and renal cytokine interleukin (IL)-12 levels were lower in the mice with old BM cells at 24 hours post-IRI. Consistently, the in vitro study showed that LPS-induced production of cytokines interferon-γ, monocyte chemoattractant protein-1, and IL-10 was attenuated in cultured old BM cells, suggesting that age-related functional changes in these cells may lead to reduced inflammation in IRI. Conclusion: Immunosenescence could affect the susceptibility and response to renal IRI. Further studies specifically addressing age-related alterations can help in the development of treatment strategies for elderly patients with AKI.

    Original languageEnglish
    Pages (from-to)25-32
    Number of pages8
    JournalKidney Research and Clinical Practice
    Issue number1
    Publication statusPublished - 2019 Mar


    • Acute kidney injury
    • Aging
    • Immunosenescence
    • Ischemia reperfusion injury

    ASJC Scopus subject areas

    • Nephrology
    • Urology


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