TY - JOUR
T1 - The sequential change of MRI signal intensity in normal liver after radiotherapy for hepatocellular carcinoma
AU - Lee, Nam Kwon
AU - Yoon, Won Sup
AU - Lee, Jung Ae
AU - Lee, Suk
AU - Yang, Dae-Sik
AU - Kim, Chul Yong
AU - Suh, Sang Jun
AU - Yim, Hyung Joon
AU - Yeom, Suk Keu
AU - Chung, Hwan Hoon
PY - 2016/6/1
Y1 - 2016/6/1
N2 - To differentiate the interval change of irradiated normal liver from other pathologic status, our study observed early and late MRI signal changes based on radiation dose distribution in normal liver after three-dimensional conformal radiotherapy. We retrospectively evaluated 21 patients with hepatocellular carcinoma who received 40 Gy/16 fractions or 54 Gy/27 fractions radiotherapy of curative aim. The early and late terms were defined as 2 to 4 months and 10 to 14 months after radiotherapy, respectively. The simulation CT, follow-up MRI, and information regarding dose distribution were fused using the deformable registration technique. We evaluated various MRI image sets after gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid enhancement. The five regions of interest were drawn according to radiation dose distribution (Vx: The volume corresponding to the range of total irradiation dose; V>90%, V60-90%, V30-60%, V5-30%, and V<5%), and an ANOVA test was performed to compare signal differences between regions. We analyzed 19 and 11 cases of early and late term MRIs, respectively. In the early and late term, the V>90% of hepatobiliary phase images (p < 0.001 and p = 0.005, respectively) and T2-weighted images (p = 0.048 and p <0.001, respectively) were stratified with other regions showing the low and high signal, respectively. High radiation dose with curative intent can affect MRI signals on hepatobiliary phase and T2-weighted images.
AB - To differentiate the interval change of irradiated normal liver from other pathologic status, our study observed early and late MRI signal changes based on radiation dose distribution in normal liver after three-dimensional conformal radiotherapy. We retrospectively evaluated 21 patients with hepatocellular carcinoma who received 40 Gy/16 fractions or 54 Gy/27 fractions radiotherapy of curative aim. The early and late terms were defined as 2 to 4 months and 10 to 14 months after radiotherapy, respectively. The simulation CT, follow-up MRI, and information regarding dose distribution were fused using the deformable registration technique. We evaluated various MRI image sets after gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid enhancement. The five regions of interest were drawn according to radiation dose distribution (Vx: The volume corresponding to the range of total irradiation dose; V>90%, V60-90%, V30-60%, V5-30%, and V<5%), and an ANOVA test was performed to compare signal differences between regions. We analyzed 19 and 11 cases of early and late term MRIs, respectively. In the early and late term, the V>90% of hepatobiliary phase images (p < 0.001 and p = 0.005, respectively) and T2-weighted images (p = 0.048 and p <0.001, respectively) were stratified with other regions showing the low and high signal, respectively. High radiation dose with curative intent can affect MRI signals on hepatobiliary phase and T2-weighted images.
KW - Deformable registration
KW - Dose distribution
KW - Hepatocellular carcinoma
KW - MRI
KW - Radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=84975705557&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84975705557&partnerID=8YFLogxK
U2 - 10.1166/jmihi.2016.1739
DO - 10.1166/jmihi.2016.1739
M3 - Article
AN - SCOPUS:84975705557
SN - 2156-7018
VL - 6
SP - 731
EP - 738
JO - Journal of Medical Imaging and Health Informatics
JF - Journal of Medical Imaging and Health Informatics
IS - 3
ER -