Abstract
Objective: The objective of this study was to investigate the usefulness of muscle ultrasound for evaluating muscle changes caused by denervation in carpal tunnel syndrome (CTS), which is a focal neuropathy. Methods: The mean and standard deviation (SD) of echo intensity (EI) in the thenar and hypothenar muscles were calculated in 35 patients with CTS and 11 healthy subjects. Patients were assigned to three subgroups based on CTS severity as determined by electrodiagnostic tests. The ratio of thenar muscle pixel brightness to hypothenar muscle pixel brightness was used in statistical analyses. The ratio of mean pixel brightness was termed the EI ratio, and the ratio of the SD of pixel brightness was termed the inhomogeneity ratio. Results: Both the EI ratio and the inhomogeneity ratio were significantly higher in the patient group than in the control group. In a comparison of the three patient subgroups, the severe group showed significant differences in both the EI and inhomogeneity ratios compared to the other two groups. Subjects with denervation potential in the abductor pollicis brevis (APB) had higher EI and inhomogeneity ratios than subjects without denervation potential in the APB. Conclusion: The EI ratio and inhomogeneity ratio are useful variables with which to evaluate disease severity and the presence of denervation in patients with CTS. Significance: Muscle ultrasound has clinical significance in the detection of muscle changes that result from neuropathy.
Original language | English |
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Pages (from-to) | 880-885 |
Number of pages | 6 |
Journal | Clinical Neurophysiology |
Volume | 127 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2016 Jan 1 |
Externally published | Yes |
Bibliographical note
Funding Information:This work was supported by the Technology Innovation Program (or the Industrial Strategic Technology Development Program) (10049743, “Establishing a medical device development open platform, as a hub for accelerating close firm-hospital communication”) funded by the Ministry of Trade, Industry and Energy (MI, Korea).
Publisher Copyright:
© 2015 International Federation of Clinical Neurophysiology.
Keywords
- Muscle echo intensity
- Neuropathy
- Ultrasound
ASJC Scopus subject areas
- Sensory Systems
- Neurology
- Clinical Neurology
- Physiology (medical)