The solid-phase synthesis of amino acid-derived diacetylene lipids

Jong Man Kim, Jun Park Bum, Eun Ju Chang, Chul Yi Sung, Hack Suh Dong, June Ahn Dong

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


We prepared amino acid-derived diacetylene monomers using solid-phase organic synthesis. The solid-phase synthetic method allowed for the rapid and efficient preparation of functional diacetylenes. Amino acids having hydrophobic sidechains such as alanine, leucine, and phenylalanine, as well as hydrophilic sidechains such as aspartic acid and lysine, were successfully coupled to the diacetylene lipid. The diacetylene monomers prepared in this way were subjected to routine procedures for the generation of polydiacetylene vesicles. Depending on the nature of the side-chains, pink to blue colored polydiacetylenes were generated.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalMacromolecular Research
Issue number3
Publication statusPublished - 2005 Jun


  • Amino acids
  • Diacetylene
  • Solid-phase synthesis

ASJC Scopus subject areas

  • General Chemical Engineering
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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