The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease

Yong Park; Dae Sik Kim; Seh Jong Park; Hee Yun Seo; Se Ryeon Lee; Hwa Jung Sung; Kyong Hwa Park; In Keun Choi; Seok Jin Kim; Sang Cheul Oh; Jae Hong Seo; Chul Won Choi; Byung Soo Kim; Sang Won Shin; Yeul Hong Kim; Jun Suk Kim

doi:10.1016/j.leukres.2009.08.024

The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease

Yong Park, Dae Sik Kim, Seh Jong Park, Hee Yun Seo, Se Ryeon Lee, Hwa Jung Sung, Kyong Hwa Park, In Keun Choi, Seok Jin Kim, Sang Cheul Oh, Jae Hong Seo, Chul Won Choi, Byung Soo Kim, Sang Won Shin, Yeul Hong Kim, Jun Suk Kim

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. Based on multivariate analysis, significant prognostic factors are recovery of neutropenia, respiratory infection, baseline serum albumin, baseline bicarbonate, baseline CRP, and CRP on the fifth day after antibiotic treatment. From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. Further studies in prospective setting are needed for the validation of this model.

Original language	English
Pages (from-to)	294-300
Number of pages	7
Journal	Leukemia Research
Volume	34
Issue number	3
DOIs	https://doi.org/10.1016/j.leukres.2009.08.024
Publication status	Published - 2010 Mar

Keywords

Albumin
Bicarbonate
C-reactive protein
Febrile neutropenia
Hematologic malignancy
Prognosis

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2009.08.024

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Park, Y., Kim, D. S., Park, S. J., Seo, H. Y., Lee, S. R., Sung, H. J., Park, K. H., Choi, I. K., Kim, S. J., Oh, S. C., Seo, J. H., Choi, C. W., Kim, B. S., Shin, S. W., Kim, Y. H., & Kim, J. S. (2010). The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease. Leukemia Research, 34(3), 294-300. https://doi.org/10.1016/j.leukres.2009.08.024

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abstract = "We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. Based on multivariate analysis, significant prognostic factors are recovery of neutropenia, respiratory infection, baseline serum albumin, baseline bicarbonate, baseline CRP, and CRP on the fifth day after antibiotic treatment. From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. Further studies in prospective setting are needed for the validation of this model.",

keywords = "Albumin, Bicarbonate, C-reactive protein, Febrile neutropenia, Hematologic malignancy, Prognosis",

author = "Yong Park and Kim, {Dae Sik} and Park, {Seh Jong} and Seo, {Hee Yun} and Lee, {Se Ryeon} and Sung, {Hwa Jung} and Park, {Kyong Hwa} and Choi, {In Keun} and Kim, {Seok Jin} and Oh, {Sang Cheul} and Seo, {Jae Hong} and Choi, {Chul Won} and Kim, {Byung Soo} and Shin, {Sang Won} and Kim, {Yeul Hong} and Kim, {Jun Suk}",

year = "2010",

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doi = "10.1016/j.leukres.2009.08.024",

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AU - Park, Yong

AU - Kim, Dae Sik

AU - Park, Seh Jong

AU - Seo, Hee Yun

AU - Lee, Se Ryeon

AU - Sung, Hwa Jung

AU - Park, Kyong Hwa

AU - Choi, In Keun

AU - Kim, Seok Jin

AU - Oh, Sang Cheul

AU - Seo, Jae Hong

AU - Choi, Chul Won

AU - Kim, Byung Soo

AU - Shin, Sang Won

AU - Kim, Yeul Hong

AU - Kim, Jun Suk

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AB - We analyzed the prognostic factors from 259 cases of febrile neutropenia occurring in 137 patients with hematologic disease. Based on multivariate analysis, significant prognostic factors are recovery of neutropenia, respiratory infection, baseline serum albumin, baseline bicarbonate, baseline CRP, and CRP on the fifth day after antibiotic treatment. From these variables, we derived a predictive model for the prognosis of febrile neutropenia using baseline serum albumin, bicarbonate, and CRP, which could be easily checked before chemotherapy. Further studies in prospective setting are needed for the validation of this model.

KW - Albumin

KW - Bicarbonate

KW - C-reactive protein

KW - Febrile neutropenia

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SN - 0145-2126

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JF - Leukemia Research

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ER -

The suggestion of a risk stratification system for febrile neutropenia in patients with hematologic disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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