The timing of external input controls the sign of plasticity at local synapses

Jeehyun Kwag; Ole Paulsen

doi:10.1038/nn.2388

The timing of external input controls the sign of plasticity at local synapses

Jeehyun Kwag, Ole Paulsen

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

Abstract

The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local synapses in rat hippocampus. This mechanism provides a means by which temporal information in external input can be encoded in the local matrix of synaptic weights.

Original language	English
Pages (from-to)	1219-1221
Number of pages	3
Journal	Nature Neuroscience
Volume	12
Issue number	10
DOIs	https://doi.org/10.1038/nn.2388
Publication status	Published - 2009 Oct
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/D0157581) and the Kwanjeong Foundation.

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1038/nn.2388

Cite this

@article{e400fdd1623a45648341727fc6170117,

title = "The timing of external input controls the sign of plasticity at local synapses",

abstract = "The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local synapses in rat hippocampus. This mechanism provides a means by which temporal information in external input can be encoded in the local matrix of synaptic weights.",

author = "Jeehyun Kwag and Ole Paulsen",

note = "Funding Information: This work was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/D0157581) and the Kwanjeong Foundation.",

year = "2009",

month = oct,

doi = "10.1038/nn.2388",

language = "English",

volume = "12",

pages = "1219--1221",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Research",

number = "10",

}

TY - JOUR

T1 - The timing of external input controls the sign of plasticity at local synapses

AU - Kwag, Jeehyun

AU - Paulsen, Ole

N1 - Funding Information: This work was supported by the Biotechnology and Biological Sciences Research Council (grant number BB/D0157581) and the Kwanjeong Foundation.

PY - 2009/10

Y1 - 2009/10

N2 - The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local synapses in rat hippocampus. This mechanism provides a means by which temporal information in external input can be encoded in the local matrix of synaptic weights.

AB - The method by which local networks in the brain store information from extrinsic afferent inputs is not well understood. We found that the timing of afferent input can bidirectionally control the sign of spike timing-dependent plasticity at local synapses in rat hippocampus. This mechanism provides a means by which temporal information in external input can be encoded in the local matrix of synaptic weights.

UR - http://www.scopus.com/inward/record.url?scp=70349554206&partnerID=8YFLogxK

U2 - 10.1038/nn.2388

DO - 10.1038/nn.2388

M3 - Article

C2 - 19734896

AN - SCOPUS:70349554206

SN - 1097-6256

VL - 12

SP - 1219

EP - 1221

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 10

ER -

The timing of external input controls the sign of plasticity at local synapses

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this