Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy

Yong Il Park; Hyung Min Kim; Jeong Hyun Kim; Kyung Chul Moon; Byeongjun Yoo; Kang Taek Lee; Nohyun Lee; Yoonseok Choi; Wooram Park; Daishun Ling; Kun Na; Woo Kyung Moon; Seung Hong Choi; Hong Seok Park; Soo Young Yoon; Yung Doug Suh; Sung Ho Lee; Taeghwan Hyeon

doi:10.1002/adma.201202433

Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy

Yong Il Park, Hyung Min Kim, Jeong Hyun Kim, Kyung Chul Moon, Byeongjun Yoo, Kang Taek Lee, Nohyun Lee, Yoonseok Choi, Wooram Park, Daishun Ling, Kun Na, Woo Kyung Moon, Seung Hong Choi, Hong Seok Park, Soo Young Yoon, Yung Doug Suh, Sung Ho Lee, Taeghwan Hyeon

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

370 Citations (Scopus)

Abstract

Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF₄:Yb,Er/NaGdF₄ core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.

Original language	English
Pages (from-to)	5755-5761
Number of pages	7
Journal	Advanced Materials
Volume	24
Issue number	42
DOIs	https://doi.org/10.1002/adma.201202433
Publication status	Published - 2012 Nov 8

Keywords

luminescence
magnetic resonance imaging
nanoparticles
photodynamic therapy
upconversion

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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Park, Y. I., Kim, H. M., Kim, J. H., Moon, K. C., Yoo, B., Lee, K. T., Lee, N., Choi, Y., Park, W., Ling, D., Na, K., Moon, W. K., Choi, S. H., Park, H. S., Yoon, S. Y., Suh, Y. D., Lee, S. H., & Hyeon, T. (2012). Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy. Advanced Materials, 24(42), 5755-5761. https://doi.org/10.1002/adma.201202433

Park, YI, Kim, HM, Kim, JH, Moon, KC, Yoo, B, Lee, KT, Lee, N, Choi, Y, Park, W, Ling, D, Na, K, Moon, WK, Choi, SH, Park, HS, Yoon, SY, Suh, YD, Lee, SH & Hyeon, T 2012, 'Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy', Advanced Materials, vol. 24, no. 42, pp. 5755-5761. https://doi.org/10.1002/adma.201202433

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abstract = "Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.",

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AU - Park, Yong Il

AU - Kim, Hyung Min

AU - Kim, Jeong Hyun

AU - Moon, Kyung Chul

AU - Yoo, Byeongjun

AU - Lee, Kang Taek

AU - Lee, Nohyun

AU - Choi, Yoonseok

AU - Park, Wooram

AU - Ling, Daishun

AU - Na, Kun

AU - Moon, Woo Kyung

AU - Choi, Seung Hong

AU - Park, Hong Seok

AU - Yoon, Soo Young

AU - Suh, Yung Doug

AU - Lee, Sung Ho

AU - Hyeon, Taeghwan

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AB - Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.

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KW - magnetic resonance imaging

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Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy

Abstract

Keywords

ASJC Scopus subject areas

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