Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy

Yong Il Park, Hyung Min Kim, Jeong Hyun Kim, Kyung Chul Moon, Byeongjun Yoo, Kang Taek Lee, Nohyun Lee, Yoonseok Choi, Wooram Park, Daishun Ling, Kun Na, Woo Kyung Moon, Seung Hong Choi, Hong Seok Park, Soo Young Yoon, Yung Doug Suh, Sung Ho Lee, Taeghwan Hyeon

    Research output: Contribution to journalArticlepeer-review

    386 Citations (Scopus)

    Abstract

    Dual-modal in vivo tumor imaging and photodynamic therapy using hexagonal NaYF4:Yb,Er/NaGdF4 core-shell upconverting nanoparticles combined with a photosensitizer, chlorin e6, is reported. Tumors can be clearly observed not only in the upconversion luminescence image but also in the magnetic resonance image. In vivo photodynamic therapy by systemic administration is demonstrated under 980 nm irradiation.

    Original languageEnglish
    Pages (from-to)5755-5761
    Number of pages7
    JournalAdvanced Materials
    Volume24
    Issue number42
    DOIs
    Publication statusPublished - 2012 Nov 8

    Keywords

    • luminescence
    • magnetic resonance imaging
    • nanoparticles
    • photodynamic therapy
    • upconversion

    ASJC Scopus subject areas

    • General Materials Science
    • Mechanics of Materials
    • Mechanical Engineering

    Fingerprint

    Dive into the research topics of 'Theranostic probe based on lanthanide-doped nanoparticles for simultaneous in vivo dual-modal imaging and photodynamic therapy'. Together they form a unique fingerprint.

    Cite this