Therapeutic effect of korean red ginseng extract on infertility caused by polycystic ovaries

Ji Hun Jung; Hyun Tae Park; Tak Kim; Moon Jin Jeong; Sung Chul Lim; Seung Yeol Nah; Ik Hyun Cho; Soo Hyun Park; Seong Soo Kang; Chang Jong Moon; Jong Choon Kim; Sung Ho Kim; Chun Sik Bae

doi:10.5142/jgr.2011.35.2.250

Therapeutic effect of korean red ginseng extract on infertility caused by polycystic ovaries

Ji Hun Jung, Hyun Tae Park, Tak Kim, Moon Jin Jeong, Sung Chul Lim, Seung Yeol Nah, Ik Hyun Cho, Soo Hyun Park, Seong Soo Kang, Chang Jong Moon, Jong Choon Kim, Sung Ho Kim, Chun Sik Bae

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Polycystic ovarian syndrome (PCOS) is a very common endocrine disorder in women of reproductive age. Nerve growth factor (NGF) may be involved in the pathogenesis of PCOS. In this study, we investigated the effect of Korean red ginseng extract (KRGE) on the ovarian morphology and NGF expression in an estradiol valerate (EV)-induced rat model. Polycystic ovaries were induced by a single intramuscular injection of estadiol valerate (4 mg, dissolved in sesame oil) in adult cycling rats. KRGE was administered orally (200 mg/kg body weight/day) for 60 consecutive days, beginning 60 days after the induction. Ovarian morphology was almost normalized and NGF was normalized in the EV+KRGE group. KRGE lowered the high numbers of antral follicles and increased the number of corpora lutea in the polycystic ovaries. The results are consistent with a beneficial effect of KRGE in the treatment of PCOS.

Original language	English
Pages (from-to)	250-255
Number of pages	6
Journal	Journal of Ginseng Research
Volume	35
Issue number	2
DOIs	https://doi.org/10.5142/jgr.2011.35.2.250
Publication status	Published - 2011 Jun
Externally published	Yes

Keywords

Estradiol valerate
Ginseng extract
Panax ginseng
Pathophysiology
Polycystic ovary syndrome

ASJC Scopus subject areas

Biotechnology
Biochemistry, Genetics and Molecular Biology (miscellaneous)
Complementary and alternative medicine

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10.5142/jgr.2011.35.2.250

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title = "Therapeutic effect of korean red ginseng extract on infertility caused by polycystic ovaries",

abstract = "Polycystic ovarian syndrome (PCOS) is a very common endocrine disorder in women of reproductive age. Nerve growth factor (NGF) may be involved in the pathogenesis of PCOS. In this study, we investigated the effect of Korean red ginseng extract (KRGE) on the ovarian morphology and NGF expression in an estradiol valerate (EV)-induced rat model. Polycystic ovaries were induced by a single intramuscular injection of estadiol valerate (4 mg, dissolved in sesame oil) in adult cycling rats. KRGE was administered orally (200 mg/kg body weight/day) for 60 consecutive days, beginning 60 days after the induction. Ovarian morphology was almost normalized and NGF was normalized in the EV+KRGE group. KRGE lowered the high numbers of antral follicles and increased the number of corpora lutea in the polycystic ovaries. The results are consistent with a beneficial effect of KRGE in the treatment of PCOS.",

keywords = "Estradiol valerate, Ginseng extract, Panax ginseng, Pathophysiology, Polycystic ovary syndrome",

author = "Jung, {Ji Hun} and Park, {Hyun Tae} and Tak Kim and Jeong, {Moon Jin} and Lim, {Sung Chul} and Nah, {Seung Yeol} and Cho, {Ik Hyun} and Park, {Soo Hyun} and Kang, {Seong Soo} and Moon, {Chang Jong} and Kim, {Jong Choon} and Kim, {Sung Ho} and Bae, {Chun Sik}",

year = "2011",

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doi = "10.5142/jgr.2011.35.2.250",

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AU - Jung, Ji Hun

AU - Park, Hyun Tae

AU - Kim, Tak

AU - Jeong, Moon Jin

AU - Lim, Sung Chul

AU - Nah, Seung Yeol

AU - Cho, Ik Hyun

AU - Park, Soo Hyun

AU - Kang, Seong Soo

AU - Moon, Chang Jong

AU - Kim, Jong Choon

AU - Kim, Sung Ho

AU - Bae, Chun Sik

PY - 2011/6

Y1 - 2011/6

N2 - Polycystic ovarian syndrome (PCOS) is a very common endocrine disorder in women of reproductive age. Nerve growth factor (NGF) may be involved in the pathogenesis of PCOS. In this study, we investigated the effect of Korean red ginseng extract (KRGE) on the ovarian morphology and NGF expression in an estradiol valerate (EV)-induced rat model. Polycystic ovaries were induced by a single intramuscular injection of estadiol valerate (4 mg, dissolved in sesame oil) in adult cycling rats. KRGE was administered orally (200 mg/kg body weight/day) for 60 consecutive days, beginning 60 days after the induction. Ovarian morphology was almost normalized and NGF was normalized in the EV+KRGE group. KRGE lowered the high numbers of antral follicles and increased the number of corpora lutea in the polycystic ovaries. The results are consistent with a beneficial effect of KRGE in the treatment of PCOS.

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Therapeutic effect of korean red ginseng extract on infertility caused by polycystic ovaries

Abstract

Keywords

ASJC Scopus subject areas

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