Thermal immuno-nanomedicine in cancer

Zhe Yang, Di Gao, Jing Zhao, Gaojie Yang, Ming Guo, Ying Wang, Xuechun Ren, Jong Seung Kim, Lin Jin, Zhongmin Tian, Xingcai Zhang

Research output: Contribution to journalReview articlepeer-review

49 Citations (Scopus)


Immunotherapy has revolutionized the treatment of patients with cancer. However, promoting antitumour immunity in patients with tumours that are resistant to these therapies remains a challenge. Thermal therapies provide a promising immune-adjuvant strategy for use with immunotherapy, mostly owing to the capacity to reprogramme the tumour microenvironment through induction of immunogenic cell death, which also promotes the recruitment of endogenous immune cells. Thus, thermal immunotherapeutic strategies for various cancers are an area of considerable research interest. In this Review, we describe the role of the various thermal therapies and provide an update on attempts to combine these with immunotherapies in clinical trials. We also provide an overview of the preclinical development of various thermal immuno-nanomedicines, which are capable of combining thermal therapies with various immunotherapy strategies in a single therapeutic platform. Finally, we discuss the challenges associated with the clinical translation of thermal immuno-nanomedicines and emphasize the importance of multidisciplinary and inter-professional collaboration to facilitate the optimal translation of this technology from bench to bedside.

Original languageEnglish
Pages (from-to)116-134
Number of pages19
JournalNature Reviews Clinical Oncology
Issue number2
Publication statusPublished - 2023 Feb

Bibliographical note

Publisher Copyright:
© 2023, Springer Nature Limited.

ASJC Scopus subject areas

  • Oncology


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