Thermal stability of yeast hydrolysate as a novel anti-obesity material

Yooheon Park; Jae Hwan Kim; Hyun Sun Lee; Eun Young Jung; Hyunji Lee; Dong Ouk Noh; Hyung Joo Suh

doi:10.1016/j.foodchem.2012.08.047

Thermal stability of yeast hydrolysate as a novel anti-obesity material

Yooheon Park, Jae Hwan Kim, Hyun Sun Lee, Eun Young Jung, Hyunji Lee, Dong Ouk Noh, Hyung Joo Suh

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We examined the thermal stability of yeast hydrolysates before and after ultrafiltration (UF) in vitro, and the anti-obesity activity of yeast hydrolysates before and after heat treatment in vivo. Yeast hydrolysate after UF showed significantly higher thermal stability than before UF. Yeast hydrolysates before and after UF showed 3 and 4 thermal transition peaks in their thermograms, respectively, and the total thermal denaturation enthalpies of yeast hydrolysates before and after UF were 69.5 and 36.5 J/g, respectively. For the anti-obesity activity study, yeast hydrolysates before and after heating were administered ad libitum with water to 7-week-old male SD rats. The administration of yeast hydrolysate (YH-control; no heat treatment, YH-1; heat treatment at 140 °C, and YH-2; heat treatment at 160 °C) significantly increased mRNA expression of cocaine- and amphetamine-regulated transcript (CART) compared with control rats (saline administration). However, there was no significant difference between the heat-treated groups and YH-control and there was no significant difference in neuropeptide Y expression between the heat-treated groups and YH-control. These results suggest that yeast hydrolysate can be use an anti-obesity material after heat treatment.

Original language	English
Pages (from-to)	316-321
Number of pages	6
Journal	Food Chemistry
Volume	136
Issue number	2
DOIs	https://doi.org/10.1016/j.foodchem.2012.08.047
Publication status	Published - 2013 Jan 15

Bibliographical note

Funding Information:
This work was supported by Korea Small and Medium Business Administration in 2010 ( Business for Cooperative R&D between Industry, Academy, and Research Institute , Grants No. 00041607-1 ).

Keywords

CART
NPY
Thermal stability
Yeast hydrolysate

ASJC Scopus subject areas

Analytical Chemistry
Food Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.foodchem.2012.08.047

Cite this

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title = "Thermal stability of yeast hydrolysate as a novel anti-obesity material",

abstract = "We examined the thermal stability of yeast hydrolysates before and after ultrafiltration (UF) in vitro, and the anti-obesity activity of yeast hydrolysates before and after heat treatment in vivo. Yeast hydrolysate after UF showed significantly higher thermal stability than before UF. Yeast hydrolysates before and after UF showed 3 and 4 thermal transition peaks in their thermograms, respectively, and the total thermal denaturation enthalpies of yeast hydrolysates before and after UF were 69.5 and 36.5 J/g, respectively. For the anti-obesity activity study, yeast hydrolysates before and after heating were administered ad libitum with water to 7-week-old male SD rats. The administration of yeast hydrolysate (YH-control; no heat treatment, YH-1; heat treatment at 140 °C, and YH-2; heat treatment at 160 °C) significantly increased mRNA expression of cocaine- and amphetamine-regulated transcript (CART) compared with control rats (saline administration). However, there was no significant difference between the heat-treated groups and YH-control and there was no significant difference in neuropeptide Y expression between the heat-treated groups and YH-control. These results suggest that yeast hydrolysate can be use an anti-obesity material after heat treatment.",

keywords = "CART, NPY, Thermal stability, Yeast hydrolysate",

author = "Yooheon Park and Kim, {Jae Hwan} and Lee, {Hyun Sun} and Jung, {Eun Young} and Hyunji Lee and Noh, {Dong Ouk} and Suh, {Hyung Joo}",

note = "Funding Information: This work was supported by Korea Small and Medium Business Administration in 2010 ( Business for Cooperative R&D between Industry, Academy, and Research Institute , Grants No. 00041607-1 ).",

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doi = "10.1016/j.foodchem.2012.08.047",

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AU - Park, Yooheon

AU - Kim, Jae Hwan

AU - Lee, Hyun Sun

AU - Jung, Eun Young

AU - Lee, Hyunji

AU - Noh, Dong Ouk

AU - Suh, Hyung Joo

N1 - Funding Information: This work was supported by Korea Small and Medium Business Administration in 2010 ( Business for Cooperative R&D between Industry, Academy, and Research Institute , Grants No. 00041607-1 ).

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N2 - We examined the thermal stability of yeast hydrolysates before and after ultrafiltration (UF) in vitro, and the anti-obesity activity of yeast hydrolysates before and after heat treatment in vivo. Yeast hydrolysate after UF showed significantly higher thermal stability than before UF. Yeast hydrolysates before and after UF showed 3 and 4 thermal transition peaks in their thermograms, respectively, and the total thermal denaturation enthalpies of yeast hydrolysates before and after UF were 69.5 and 36.5 J/g, respectively. For the anti-obesity activity study, yeast hydrolysates before and after heating were administered ad libitum with water to 7-week-old male SD rats. The administration of yeast hydrolysate (YH-control; no heat treatment, YH-1; heat treatment at 140 °C, and YH-2; heat treatment at 160 °C) significantly increased mRNA expression of cocaine- and amphetamine-regulated transcript (CART) compared with control rats (saline administration). However, there was no significant difference between the heat-treated groups and YH-control and there was no significant difference in neuropeptide Y expression between the heat-treated groups and YH-control. These results suggest that yeast hydrolysate can be use an anti-obesity material after heat treatment.

AB - We examined the thermal stability of yeast hydrolysates before and after ultrafiltration (UF) in vitro, and the anti-obesity activity of yeast hydrolysates before and after heat treatment in vivo. Yeast hydrolysate after UF showed significantly higher thermal stability than before UF. Yeast hydrolysates before and after UF showed 3 and 4 thermal transition peaks in their thermograms, respectively, and the total thermal denaturation enthalpies of yeast hydrolysates before and after UF were 69.5 and 36.5 J/g, respectively. For the anti-obesity activity study, yeast hydrolysates before and after heating were administered ad libitum with water to 7-week-old male SD rats. The administration of yeast hydrolysate (YH-control; no heat treatment, YH-1; heat treatment at 140 °C, and YH-2; heat treatment at 160 °C) significantly increased mRNA expression of cocaine- and amphetamine-regulated transcript (CART) compared with control rats (saline administration). However, there was no significant difference between the heat-treated groups and YH-control and there was no significant difference in neuropeptide Y expression between the heat-treated groups and YH-control. These results suggest that yeast hydrolysate can be use an anti-obesity material after heat treatment.

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Thermal stability of yeast hydrolysate as a novel anti-obesity material

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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