Thermostable cellulases: Current status and perspectives

Anil K. Patel, Reeta Rani Singhania, Sang Jun Sim, Ashok Pandey

Research output: Contribution to journalReview articlepeer-review

179 Citations (Scopus)


It is envisaged that the utilization of lignocellulosic biomass for ethanol production for transport sector, would make cellulases the most demanded industrial enzyme. The greatest potential of cellulolytic enzymes lies in ethanol production from biomass by enzymatic hydrolysis of cellulose but low thermostability and low titer of cellulase production resulting into high cost of the enzyme which is the major set-back. A number of research groups are working on cellulase to improve its thermostability so as to be able to perform hydrolysis at elevated temperatures which would eventually increase the efficiency of cellulose hydrolysis. The technologies developed from lignocellulosic biomass via cellulose hydrolysis promise environmental and economical sustainability in the long run along with non-dependence on nonrenewable energy source. This review deals with the important sources of thermostable cellulases, mechanism, its regulation, strategies to enhance the thermostability further with respect to its importance for biofuel applications.

Original languageEnglish
Pages (from-to)385-392
Number of pages8
JournalBioresource technology
Publication statusPublished - 2019 May

Bibliographical note

Publisher Copyright:
© 2019


  • Bioethanol
  • Cellulases
  • Lignocellulose biomass
  • Thermophiles
  • Thermostability

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal


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